Differential effects of respiratory and electrical stimulation-induced dilator muscle contraction on mechanical properties of the pharynx in the pig

A. Brodsky, Y. Dotan, M. Samri, Alan R Schwartz, A. Oliven

Research output: Contribution to journalArticle

Abstract

First published June 16, 2016; doi:10.1152/japplphysiol.00783.2015.-Respiratory stimulation (RS) during sleep often fails to discontinue flow limitation, whereas electrical stimulation (ES) of the hypoglossus (HG) nerve frequently prevents obstruction. The present work compares the effects of RS and HG-ES on pharyngeal mechanics and the relative contribution of tongue muscles and thoracic forces to pharyngeal patency. We determined the pressure-area relationship of the collapsible segment of the pharynx in anesthetized pigs under the following three conditions: baseline (BL), RS induced by partial obstruction of the tracheostomy tube, and HG-ES. Parameters were obtained also after transection of the neck muscles and the trachea (NMT) and after additional bilateral HG transection (HGT). In addition, we measured the force produced by in situ isolated geniohyoid (GH) during RS and HG-ES. Intense RS was recognized by large negative intrathoracic pressures and triggered high phasic genioglossus and GH EMG activity. GH contraction produced during maximal RS less than a quarter of the force obtained during HG-ES. The major finding of the study was that RS and ES differed in the mechanism by which they stabilized the pharynx: RS lowered the pressure-area slope, i.e., reduced pharyngeal compliance (14.1=2.9 to 9.2=1.9 mm2/ cmH2O, P<0.01). HG-ES shifted the slope toward lower pressures, i.e., lowered the calculated extraluminal pressure (17.4=5.8 to 9.2=7.4 cmH2O, P<0.01). Changes during RS and HG-ES were not affected by NMT, but the effect of RS decreased significantly after HGT. In conclusion, HG-ES and RS affect the pharyngeal site of collapse differently. Tongue muscle contraction contributes to pharyngeal stiffening during RS.

Original languageEnglish (US)
Pages (from-to)606-614
Number of pages9
JournalJournal of Applied Physiology
Volume121
Issue number3
DOIs
StatePublished - Sep 1 2016

Fingerprint

Muscle Contraction
Pharynx
Electric Stimulation
Swine
Pressure
Neck Muscles
Trachea
Tongue
Tracheostomy
Mechanics
Compliance
Sleep
Thorax
Muscles

Keywords

  • Control of breathing
  • Obstructive sleep apnea
  • Respiratory stimulation
  • Upper airway

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Differential effects of respiratory and electrical stimulation-induced dilator muscle contraction on mechanical properties of the pharynx in the pig. / Brodsky, A.; Dotan, Y.; Samri, M.; Schwartz, Alan R; Oliven, A.

In: Journal of Applied Physiology, Vol. 121, No. 3, 01.09.2016, p. 606-614.

Research output: Contribution to journalArticle

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