Differential effects of phosphodiesterase type 4-specific inhibition on human autoreactive myelin-specific T cell clones

Martin Pette, Paolo A. Muraro, Dagmar F. Pette, H. Dinter, Henry F. McFarland, Roland Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Proinflammatory cytokines, secreted by autoreactive CD4+ T lymphocytes may contribute to the pathogenesis of several human autoimmune diseases, including multiple sclerosis (MS). Since the antigen specificities of these T cells are not known at present, therapeutic strategies aiming at common effector pathways, in particular cytokine secretion, may be more feasible in the near future. We have studied the influence of the isoenzyme-specific phosphodiesterase inhibitor rolipram on the proliferation and cytokine secretion of human myelin basic protein-specific T cell clones. The inhibition of proliferation correlated with interference with the IL-2/IL-2 receptor system, while the effects of rolipram on several T helper 1-(TNF-α, TNF-β, IFN-γ) and T helper 2-like cytokines (IL-4, IL-13) as well as IL-10 revealed an interesting drug profile, with preferential inhibition of TNF-β, TNF-α and IL-10. This profile suggest that rolipram differs from other currently used immunomodulatory drugs. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalJournal of Neuroimmunology
Volume98
Issue number2
DOIs
StatePublished - Aug 3 1999
Externally publishedYes

Keywords

  • Multiple sclerosis
  • Phosphodiesterase inhibition
  • Rolipram
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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