Abstract
The effects of oral contraceptive steroids (OCS) on the disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide were examined. Lorazepam and oxazepam are metabolized via glucuronidation while chlordiazepoxide is metabolized by oxidation in the liver. The disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide was studied in females not taking OCS and females taking OCS (norethindrone acetate, 1 mg; ethinyl estradiol, 50 μg) for 6 months or more. The t 1/2 (β) for lorazepam was significantly reduced in women taking OCS (6.0 ± 3.1 vs. 14.0 ± 6.2 hr) (p <0.005) as compared to controls, and the t 1/2 (β) for oxazepam was reduced in women taking OCS (7.71 ± 3.23 vs. 12.09 ± 5.08 hr) as compared to controls, but did not reach statistical significance. The plasma clearance of both lorazepam and oxazepam was significantly increased in women taking OCS [(288.9 ± 165.9 vs. 77.5 ± 3.29 ml per min) (p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-253 |
| Number of pages | 6 |
| Journal | Hepatology |
| Volume | 3 |
| Issue number | 2 |
| State | Published - 1983 |
Fingerprint
ASJC Scopus subject areas
- Hepatology
Cite this
Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines. / Patwardhan, R. V.; Mitchell, M. C.; Johnson, R. F.; Schenker, S.
In: Hepatology, Vol. 3, No. 2, 1983, p. 248-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines
AU - Patwardhan, R. V.
AU - Mitchell, M. C.
AU - Johnson, R. F.
AU - Schenker, S.
PY - 1983
Y1 - 1983
N2 - The effects of oral contraceptive steroids (OCS) on the disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide were examined. Lorazepam and oxazepam are metabolized via glucuronidation while chlordiazepoxide is metabolized by oxidation in the liver. The disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide was studied in females not taking OCS and females taking OCS (norethindrone acetate, 1 mg; ethinyl estradiol, 50 μg) for 6 months or more. The t 1/2 (β) for lorazepam was significantly reduced in women taking OCS (6.0 ± 3.1 vs. 14.0 ± 6.2 hr) (p <0.005) as compared to controls, and the t 1/2 (β) for oxazepam was reduced in women taking OCS (7.71 ± 3.23 vs. 12.09 ± 5.08 hr) as compared to controls, but did not reach statistical significance. The plasma clearance of both lorazepam and oxazepam was significantly increased in women taking OCS [(288.9 ± 165.9 vs. 77.5 ± 3.29 ml per min) (p
AB - The effects of oral contraceptive steroids (OCS) on the disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide were examined. Lorazepam and oxazepam are metabolized via glucuronidation while chlordiazepoxide is metabolized by oxidation in the liver. The disposition and elimination of lorazepam, oxazepam, and chlordiazepoxide was studied in females not taking OCS and females taking OCS (norethindrone acetate, 1 mg; ethinyl estradiol, 50 μg) for 6 months or more. The t 1/2 (β) for lorazepam was significantly reduced in women taking OCS (6.0 ± 3.1 vs. 14.0 ± 6.2 hr) (p <0.005) as compared to controls, and the t 1/2 (β) for oxazepam was reduced in women taking OCS (7.71 ± 3.23 vs. 12.09 ± 5.08 hr) as compared to controls, but did not reach statistical significance. The plasma clearance of both lorazepam and oxazepam was significantly increased in women taking OCS [(288.9 ± 165.9 vs. 77.5 ± 3.29 ml per min) (p
UR - http://www.scopus.com/inward/record.url?scp=0020678824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020678824&partnerID=8YFLogxK
M3 - Article
C2 - 6131860
AN - SCOPUS:0020678824
VL - 3
SP - 248
EP - 253
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 2
ER -