Differential effects of methylphenidate on reticular formation and thalamic neuronal activity

Tsung Ming Shih, Zaven S. Khachaturian, Herbert Barry, Kurt L. Reisler

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous administration of methylphenidate (1 or 2 mg/kg) markedly attenuated the unit discharge rate in the mesencephalic reticular formation of rats and cats. Concurrently this drug enhanced the neural activity in the primary sensory nuclei of the thalamus. The differential effects of methylphenidate on these two neural systems suggest a possible mechanism by which it may improve attentive processes in hyperkinesis.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalPsychopharmacology
Volume44
Issue number1
DOIs
StatePublished - Jan 1975
Externally publishedYes

Keywords

  • Arousal
  • Attention
  • CNS
  • Hyperkinesis
  • Mesencephalic Reticular Formation
  • Methylphenidate
  • Thalamus

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

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