Differential diagnosis of undifferentiated malignant tumors with monoclonal antibody T29/33

Michael J Borowitz, Gordana Stevanovic, Marcia Gottfried

Research output: Contribution to journalArticle

Abstract

An immunoperoxidase method for distinguishing lymphomas from nonlymphoid neoplasms with monoclonal antibody T29/33 is described. This antibody recognizes a 200,000-dalton pan-hematopoietic glycoprotein antigen. Staining in nearly 200 hematopoietic tumors was positive for T29/33, although three of six plasmacytomas were negative for this antibody. Five undifferentiated tumors that were proved to be lymphomas by subsequent electron microscopic and immunohistologic studies were positive for T29/33. Conversely, 11 of 12 undifferentiated tumors with ultrastructural and clinical features of carcinoma or sarcoma coma were T29/33-negative. The only exception was one sarcoma that was T29/33-positive. Thus, monoclonal antibody T29/33 is a valuable tool for characterizing neoplasms that cannot be diagnosed by histopathologic examination alone.

Original languageEnglish (US)
Pages (from-to)928-934
Number of pages7
JournalHuman Pathology
Volume15
Issue number10
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Differential Diagnosis
Monoclonal Antibodies
Neoplasms
Sarcoma
Lymphoma
Plasmacytoma
Antibodies
Coma
Glycoproteins
Electrons
Staining and Labeling
Carcinoma
Antigens

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Differential diagnosis of undifferentiated malignant tumors with monoclonal antibody T29/33. / Borowitz, Michael J; Stevanovic, Gordana; Gottfried, Marcia.

In: Human Pathology, Vol. 15, No. 10, 1984, p. 928-934.

Research output: Contribution to journalArticle

Borowitz, Michael J ; Stevanovic, Gordana ; Gottfried, Marcia. / Differential diagnosis of undifferentiated malignant tumors with monoclonal antibody T29/33. In: Human Pathology. 1984 ; Vol. 15, No. 10. pp. 928-934.
@article{e9a6e6fd3e8a4a898f3b826602557526,
title = "Differential diagnosis of undifferentiated malignant tumors with monoclonal antibody T29/33",
abstract = "An immunoperoxidase method for distinguishing lymphomas from nonlymphoid neoplasms with monoclonal antibody T29/33 is described. This antibody recognizes a 200,000-dalton pan-hematopoietic glycoprotein antigen. Staining in nearly 200 hematopoietic tumors was positive for T29/33, although three of six plasmacytomas were negative for this antibody. Five undifferentiated tumors that were proved to be lymphomas by subsequent electron microscopic and immunohistologic studies were positive for T29/33. Conversely, 11 of 12 undifferentiated tumors with ultrastructural and clinical features of carcinoma or sarcoma coma were T29/33-negative. The only exception was one sarcoma that was T29/33-positive. Thus, monoclonal antibody T29/33 is a valuable tool for characterizing neoplasms that cannot be diagnosed by histopathologic examination alone.",
author = "Borowitz, {Michael J} and Gordana Stevanovic and Marcia Gottfried",
year = "1984",
doi = "10.1016/S0046-8177(84)80122-7",
language = "English (US)",
volume = "15",
pages = "928--934",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "10",

}

TY - JOUR

T1 - Differential diagnosis of undifferentiated malignant tumors with monoclonal antibody T29/33

AU - Borowitz, Michael J

AU - Stevanovic, Gordana

AU - Gottfried, Marcia

PY - 1984

Y1 - 1984

N2 - An immunoperoxidase method for distinguishing lymphomas from nonlymphoid neoplasms with monoclonal antibody T29/33 is described. This antibody recognizes a 200,000-dalton pan-hematopoietic glycoprotein antigen. Staining in nearly 200 hematopoietic tumors was positive for T29/33, although three of six plasmacytomas were negative for this antibody. Five undifferentiated tumors that were proved to be lymphomas by subsequent electron microscopic and immunohistologic studies were positive for T29/33. Conversely, 11 of 12 undifferentiated tumors with ultrastructural and clinical features of carcinoma or sarcoma coma were T29/33-negative. The only exception was one sarcoma that was T29/33-positive. Thus, monoclonal antibody T29/33 is a valuable tool for characterizing neoplasms that cannot be diagnosed by histopathologic examination alone.

AB - An immunoperoxidase method for distinguishing lymphomas from nonlymphoid neoplasms with monoclonal antibody T29/33 is described. This antibody recognizes a 200,000-dalton pan-hematopoietic glycoprotein antigen. Staining in nearly 200 hematopoietic tumors was positive for T29/33, although three of six plasmacytomas were negative for this antibody. Five undifferentiated tumors that were proved to be lymphomas by subsequent electron microscopic and immunohistologic studies were positive for T29/33. Conversely, 11 of 12 undifferentiated tumors with ultrastructural and clinical features of carcinoma or sarcoma coma were T29/33-negative. The only exception was one sarcoma that was T29/33-positive. Thus, monoclonal antibody T29/33 is a valuable tool for characterizing neoplasms that cannot be diagnosed by histopathologic examination alone.

UR - http://www.scopus.com/inward/record.url?scp=0021743845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021743845&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(84)80122-7

DO - 10.1016/S0046-8177(84)80122-7

M3 - Article

C2 - 6384023

AN - SCOPUS:0021743845

VL - 15

SP - 928

EP - 934

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 10

ER -