Differential denaturation of Haemophilus influenzae DNA

Alan D. Cooper, P. C. Huang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The objective of this study is to determine whether differential denaturation of various genes can be observed. By treatments with heat or by titration with hydroxyl ions at subcritical levels, genetic markers from Haemophilus influenzae have been inactivated in the order of streptomycin resistance > erythromycin resistance > novobiocin resistance. The kinetics and extent of inactivation depends on whether a thermal or alkaline method is used. Results obtained with an assay system which allows the expression of single-stranded DNA are complementary to those testing the transforming activity of double-stranded DNA.

Original languageEnglish (US)
Pages (from-to)234-245
Number of pages12
JournalBBA Section Nucleic Acids And Protein Synthesis
Issue number2
StatePublished - Mar 11 1971

ASJC Scopus subject areas

  • Medicine(all)


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