TY - JOUR
T1 - Differential changes in arteriolar cerebral blood volume between parkinson’s disease patients with normal and impaired cognition and mild cognitive impairment (Mci) patients without movement disorder – an exploratory study
AU - Paez, Adrian G.
AU - Gu, Chunming
AU - Rajan, Suraj
AU - Miao, Xinyuan
AU - Cao, Di
AU - Kamath, Vidyulata
AU - Bakker, Arnold
AU - Unschuld, Paul G.
AU - Pantelyat, Alexander Y.
AU - Rosenthal, Liana S.
AU - Hua, Jun
N1 - Funding Information:
This study was supported by the Department of Defense through grant PD160104; the National Institutes of Health through grants R01-NS108452 and P41 EB015909; and KFSP Molecular Imaging Network Zurich, Swiss National Science Foundation, and institutional funding available to the Institute for Biomedical Engineering, University of Zurich, and ETH Zurich, Switzerland.
Publisher Copyright:
© 2020 The Authors. Published by Grapho Publications, LLC.
PY - 2020
Y1 - 2020
N2 - Cognitive impairment amongst Parkinson’s disease (PD) patients is highly prevalent and associated with an increased risk of dementia. There is growing evidence that altered cerebrovascular functions contribute to cognitive impairment. Few studies have compared cerebrovascular changes in PD patients with normal and impaired cognition and those with mild-cognitive-impairment (MCI) without movement disorder. Here, we investigated arteriolar-cer-ebral-blood-volume (CBVa), an index reflecting the homeostasis of the most actively regulated segment in the microvasculature, using advanced MRI in various brain regions in PD and MCI patients and matched controls. Our goal is to find brain regions with altered CBVa that are specific to PD with normal and impaired cognition, and MCI-without-movement-disorder, respectively. In PD patients with normal cognition (n=10), CBVa was significantly decreased in the substantia nigra, caudate and putamen when compared to controls. In PD patients with impaired cognition (n=6), CBVa showed a decreasing trend in the substantia nigra, caudate and putamen, but was significantly increased in the presupplementary motor area and intracalcarine gyrus compared to controls. In MCI-patients-without-movement-disorder (n=18), CBVa was significantly increased in the caudate, putamen, hippocampus and lingual gyrus compared to controls. These findings provide important information for efforts towards developing biomarkers for the evaluation of potential risk of PD dementia (PDD) in PD patients. The current study is limited in sample size and therefore is exploratory in nature. The data from this pilot study will serve as the basis for power analysis for subsequent studies to further investigate and validate the current findings.
AB - Cognitive impairment amongst Parkinson’s disease (PD) patients is highly prevalent and associated with an increased risk of dementia. There is growing evidence that altered cerebrovascular functions contribute to cognitive impairment. Few studies have compared cerebrovascular changes in PD patients with normal and impaired cognition and those with mild-cognitive-impairment (MCI) without movement disorder. Here, we investigated arteriolar-cer-ebral-blood-volume (CBVa), an index reflecting the homeostasis of the most actively regulated segment in the microvasculature, using advanced MRI in various brain regions in PD and MCI patients and matched controls. Our goal is to find brain regions with altered CBVa that are specific to PD with normal and impaired cognition, and MCI-without-movement-disorder, respectively. In PD patients with normal cognition (n=10), CBVa was significantly decreased in the substantia nigra, caudate and putamen when compared to controls. In PD patients with impaired cognition (n=6), CBVa showed a decreasing trend in the substantia nigra, caudate and putamen, but was significantly increased in the presupplementary motor area and intracalcarine gyrus compared to controls. In MCI-patients-without-movement-disorder (n=18), CBVa was significantly increased in the caudate, putamen, hippocampus and lingual gyrus compared to controls. These findings provide important information for efforts towards developing biomarkers for the evaluation of potential risk of PD dementia (PDD) in PD patients. The current study is limited in sample size and therefore is exploratory in nature. The data from this pilot study will serve as the basis for power analysis for subsequent studies to further investigate and validate the current findings.
KW - Blood vessel
KW - Dementia
KW - IVASO
KW - MRI
KW - Perfusion
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U2 - 10.18383/j.tom.2020.00033
DO - 10.18383/j.tom.2020.00033
M3 - Article
C2 - 33364423
AN - SCOPUS:85098103771
VL - 6
SP - 333
EP - 342
JO - Tomography (Ann Arbor, Mich.)
JF - Tomography (Ann Arbor, Mich.)
SN - 2379-1381
IS - 4
ER -