Differential CD4 T cell activation in measles

Diane Griffin, Brian J. Ward

Research output: Contribution to journalArticle

Abstract

Measles is associated with a vigorous antibody response without production of significant measles virus-specific delayed type hypersensitivity. Generalized disruption of immune responses also occurs during measles, including depressed skin test responses and decreased in vitro lymphocyte proliferation to mitogens. To determine if preferential activation of a subset of CD4 cells might explain these observations, the patterns of cytokines produced in vivo and in vitro during measles were determined. Soluble CD4 was elevated in plasma at all times. Interleukin (IL)-2 was increased in plasma during and shortly after the clearance of the rash and then declined. Plasma IL-4 became elevated after resolution of the rash and remained elevated in some patients through the 7-week study period. Mononuclear cells proliferated poorly in response to stimulation with anti-CD3 and produced low levels of IL-2 and interferon-γ and high levels of IL-4 and IL-6 in vitro. The defect in lymphoproliferation during convalescence was partially corrected by in vitro neutralization of IL-4. Preferential activation of type 2 cells late during measles may explain the predominant humoral immune response and the generalized suppression of cellular immune responses.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalJournal of Infectious Diseases
Volume168
Issue number2
StatePublished - Aug 1993

Fingerprint

Measles
Interleukin-4
T-Lymphocytes
Exanthema
Interleukin-2
Measles virus
Delayed Hypersensitivity
Humoral Immunity
Skin Tests
Mitogens
Cellular Immunity
Interferons
Antibody Formation
Interleukin-6
Lymphocytes
Cytokines
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Differential CD4 T cell activation in measles. / Griffin, Diane; Ward, Brian J.

In: Journal of Infectious Diseases, Vol. 168, No. 2, 08.1993, p. 275-281.

Research output: Contribution to journalArticle

Griffin, Diane ; Ward, Brian J. / Differential CD4 T cell activation in measles. In: Journal of Infectious Diseases. 1993 ; Vol. 168, No. 2. pp. 275-281.
@article{b6d9d0e70157420d8f778f492679cbca,
title = "Differential CD4 T cell activation in measles",
abstract = "Measles is associated with a vigorous antibody response without production of significant measles virus-specific delayed type hypersensitivity. Generalized disruption of immune responses also occurs during measles, including depressed skin test responses and decreased in vitro lymphocyte proliferation to mitogens. To determine if preferential activation of a subset of CD4 cells might explain these observations, the patterns of cytokines produced in vivo and in vitro during measles were determined. Soluble CD4 was elevated in plasma at all times. Interleukin (IL)-2 was increased in plasma during and shortly after the clearance of the rash and then declined. Plasma IL-4 became elevated after resolution of the rash and remained elevated in some patients through the 7-week study period. Mononuclear cells proliferated poorly in response to stimulation with anti-CD3 and produced low levels of IL-2 and interferon-γ and high levels of IL-4 and IL-6 in vitro. The defect in lymphoproliferation during convalescence was partially corrected by in vitro neutralization of IL-4. Preferential activation of type 2 cells late during measles may explain the predominant humoral immune response and the generalized suppression of cellular immune responses.",
author = "Diane Griffin and Ward, {Brian J.}",
year = "1993",
month = "8",
language = "English (US)",
volume = "168",
pages = "275--281",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Differential CD4 T cell activation in measles

AU - Griffin, Diane

AU - Ward, Brian J.

PY - 1993/8

Y1 - 1993/8

N2 - Measles is associated with a vigorous antibody response without production of significant measles virus-specific delayed type hypersensitivity. Generalized disruption of immune responses also occurs during measles, including depressed skin test responses and decreased in vitro lymphocyte proliferation to mitogens. To determine if preferential activation of a subset of CD4 cells might explain these observations, the patterns of cytokines produced in vivo and in vitro during measles were determined. Soluble CD4 was elevated in plasma at all times. Interleukin (IL)-2 was increased in plasma during and shortly after the clearance of the rash and then declined. Plasma IL-4 became elevated after resolution of the rash and remained elevated in some patients through the 7-week study period. Mononuclear cells proliferated poorly in response to stimulation with anti-CD3 and produced low levels of IL-2 and interferon-γ and high levels of IL-4 and IL-6 in vitro. The defect in lymphoproliferation during convalescence was partially corrected by in vitro neutralization of IL-4. Preferential activation of type 2 cells late during measles may explain the predominant humoral immune response and the generalized suppression of cellular immune responses.

AB - Measles is associated with a vigorous antibody response without production of significant measles virus-specific delayed type hypersensitivity. Generalized disruption of immune responses also occurs during measles, including depressed skin test responses and decreased in vitro lymphocyte proliferation to mitogens. To determine if preferential activation of a subset of CD4 cells might explain these observations, the patterns of cytokines produced in vivo and in vitro during measles were determined. Soluble CD4 was elevated in plasma at all times. Interleukin (IL)-2 was increased in plasma during and shortly after the clearance of the rash and then declined. Plasma IL-4 became elevated after resolution of the rash and remained elevated in some patients through the 7-week study period. Mononuclear cells proliferated poorly in response to stimulation with anti-CD3 and produced low levels of IL-2 and interferon-γ and high levels of IL-4 and IL-6 in vitro. The defect in lymphoproliferation during convalescence was partially corrected by in vitro neutralization of IL-4. Preferential activation of type 2 cells late during measles may explain the predominant humoral immune response and the generalized suppression of cellular immune responses.

UR - http://www.scopus.com/inward/record.url?scp=0027183947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027183947&partnerID=8YFLogxK

M3 - Article

VL - 168

SP - 275

EP - 281

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -