Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen

Johannes Stoelwinder, Marinella Roberti, Alan P. Kozikowski, Kenneth M. Johnson, John S. Bergmann

Research output: Contribution to journalArticle

Abstract

Syntheses of a variety of new N-modified cocaine analogues are reported together with their binding affinities and dopamine uptake inhibition activities. Compounds 3 and 13, which exhibit discrepancies in their binding and uptake potencies, were tested for their ability to antagonize cocaine's inhibition of dopamine reuptake.

Original languageEnglish (US)
Pages (from-to)303-308
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number2
DOIs
StatePublished - Jan 20 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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