Differential background clearance of fluorodeoxyglucose activity in normal tissues and its clinical significance

Gang Cheng, Abass Alavi, Nam Ju Lee, Scott R. Akers

Research output: Contribution to journalReview articlepeer-review

Abstract

The clearance of FDG activity in normal tissues (and thus the background level) varies significantly with extended distribution time. Although most tissues have lower SUV values on 2-hour/3-hour delayed images, others may have stable or higher FDG activity with longer distribution times. This finding has to be taken into consideration when interpreting an FDG-PET study that is performed with significantly short or long distribution time, and when comparing 2 studies with different distribution times. The continuously decreased SUV value from 1 to 3 hours in some tissues, especially in the liver, indicates that longer distribution time will decrease background activity and improve imaging quality, whereas the continuously increased SUV values from 1 to 3 hours in the heart suggest that longer distribution time will improve detection of viable myocardium in a viability study.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalPET Clinics
Volume9
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Background activity
  • Delayed imaging
  • Distribution time
  • Fluorodeoxyglucose
  • PET
  • SUV

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

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