Differential activity of pro-angiogenic CXC chemokines

Aigul Moldobaeva, Amy Baek, Lindsey Eldridge, Elizabeth Marie Wagner

Research output: Contribution to journalArticle

Abstract

We showed previously in a mouse model of lung ischemia-induced angiogenesis, enhanced expression of the three ELR+ CXC chemokines (KC, LIX, and MIP-2) and that blockade of the ligand receptor CXCR2 limited neovascularization. The present study was undertaken to determine the relative abundance and angiogenic potential of the three CXC chemokines and whether RhoA activation explained the measured differences in potencies. We found that LIX showed the greatest absolute amount in the in vivo model 4 h after left pulmonary artery obstruction (LIX>KC>MIP-2; p

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalMicrovascular Research
Volume80
Issue number1
DOIs
StatePublished - Jul 2010

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CXC Chemokines
Interleukin-8B Receptors
Pulmonary Artery
Ischemia
Chemical activation
Ligands
Lung

Keywords

  • Angiogenesis
  • Chemokines
  • Mouse arterial endothelial cells

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Differential activity of pro-angiogenic CXC chemokines. / Moldobaeva, Aigul; Baek, Amy; Eldridge, Lindsey; Wagner, Elizabeth Marie.

In: Microvascular Research, Vol. 80, No. 1, 07.2010, p. 18-22.

Research output: Contribution to journalArticle

Moldobaeva, Aigul ; Baek, Amy ; Eldridge, Lindsey ; Wagner, Elizabeth Marie. / Differential activity of pro-angiogenic CXC chemokines. In: Microvascular Research. 2010 ; Vol. 80, No. 1. pp. 18-22.
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