Differential actions of the prostaglandins on the pulmonary vascular bed.

P. J. Kadowitz, E. W. Spannhake, J. L. Levin, A. L. Hyman

Research output: Contribution to journalArticlepeer-review

Abstract

We have reported that administration of cyclooxygenase inhibitors such as indomethacin and meclofenamate results in a slow gradual increase in pulmonary vascular resistance in the intact dog (21). It has been shown that a PGI2, "like" substance is continually released by the lung (6). We have, therefore, suggested that under resting conditions, the pulmonary vascular bed is maintained in a dilated state by production of a vasodilator product in the cyclooxygenase pathway (10,21). Recent evidence suggests that this vasodilator product in the cyclooxygenase pathway is a PGI2 'like" substance (6,13,20).

Original languageEnglish (US)
Pages (from-to)731-743
Number of pages13
JournalAdvances in prostaglandin and thromboxane research
Volume7
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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