Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

Marjorie Justine Antonio, Cissy Zhang, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The beginning of the twenty-first century offered new advances in cancer research, including new knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblasts, lymphocytes, and immune cells reside, they play a crucial role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structures, metabolisms, and gene expressions, presents challenges for cancer treatment despite the advances in research. This chapter discusses how different TMEs lead to specific metabolic adaptations that drive cancer progression.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages137-147
Number of pages11
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1311
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Fatty acid oxidation
  • Heterogeneity of cancer
  • Metabolic phenotypes
  • Metabolic processes
  • Tumor microenvironments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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