Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

Marjorie Justine Antonio; Cissy Zhang; Anne Le

doi:10.1007/978-3-030-65768-0_10

Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

Marjorie Justine Antonio, Cissy Zhang, Anne Le

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

13 Scopus citations

Abstract

The beginning of the twenty-first century offered new advances in cancer research, including new knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblasts, lymphocytes, and immune cells reside, they play a crucial role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structures, metabolisms, and gene expressions, presents challenges for cancer treatment despite the advances in research. This chapter discusses how different TMEs lead to specific metabolic adaptations that drive cancer progression.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	137-147
Number of pages	11
DOIs	https://doi.org/10.1007/978-3-030-65768-0_10
State	Published - 2021

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1311
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Fatty acid oxidation
Heterogeneity of cancer
Metabolic phenotypes
Metabolic processes
Tumor microenvironments

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-030-65768-0_10

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title = "Different Tumor Microenvironments Lead to Different Metabolic Phenotypes",

abstract = "The beginning of the twenty-first century offered new advances in cancer research, including new knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblasts, lymphocytes, and immune cells reside, they play a crucial role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structures, metabolisms, and gene expressions, presents challenges for cancer treatment despite the advances in research. This chapter discusses how different TMEs lead to specific metabolic adaptations that drive cancer progression.",

keywords = "Fatty acid oxidation, Heterogeneity of cancer, Metabolic phenotypes, Metabolic processes, Tumor microenvironments",

author = "Antonio, {Marjorie Justine} and Cissy Zhang and Anne Le",

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year = "2021",

doi = "10.1007/978-3-030-65768-0_10",

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AU - Antonio, Marjorie Justine

AU - Zhang, Cissy

AU - Le, Anne

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N2 - The beginning of the twenty-first century offered new advances in cancer research, including new knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblasts, lymphocytes, and immune cells reside, they play a crucial role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structures, metabolisms, and gene expressions, presents challenges for cancer treatment despite the advances in research. This chapter discusses how different TMEs lead to specific metabolic adaptations that drive cancer progression.

AB - The beginning of the twenty-first century offered new advances in cancer research, including new knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblasts, lymphocytes, and immune cells reside, they play a crucial role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structures, metabolisms, and gene expressions, presents challenges for cancer treatment despite the advances in research. This chapter discusses how different TMEs lead to specific metabolic adaptations that drive cancer progression.

KW - Fatty acid oxidation

KW - Heterogeneity of cancer

KW - Metabolic phenotypes

KW - Metabolic processes

KW - Tumor microenvironments

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M3 - Chapter

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T3 - Advances in Experimental Medicine and Biology

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BT - Advances in Experimental Medicine and Biology

PB - Springer

ER -

Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

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Keywords

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