Different tumor microenvironments lead to different metabolic phenotypes

Marjorie Justine Antonio, Quy Hoa Le Thi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer cells adapt to changes in nutrient and oxygen availability by adopting alternative metabolic pathways.Fatty acid oxidation in cancer cells is a survival mechanism of action to glucose deprivation.Lipid scavenging is utilized to enable cancer cells to survive periods of tumor regression.Distinct, and often complementary, metabolic processes operate concurrently within a single tumor.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages119-129
Number of pages11
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Fatty acid oxidation
  • Heterogeneity of cancer
  • Metabolic phenotypes
  • Metabolic processes
  • Tumor microenvironments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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