Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: A meta-analysis

Yan Huang, Shizhong Han, Yao Li, Yumin Mao, Yi Xie

Research output: Contribution to journalArticle

Abstract

Association studies on the MTHFR polymorphisms (C677T and A1298C) in colorectal cancer (CRC) and colorectal adenoma have shown conflicting results. We performed a meta-analysis to better assess the purported associations. Overall, the 677T allele (10,131 patients and 15,362 controls) showed a small but significant protective effect against CRC compared to the 677C allele [P=0.0003, odds ratio (OR)=0.93; 95% confidence interval (CI) 0.89-0.98, P=0.22 (for heterogeneity)] for a worldwide population. Meta-analyses of other genetic contrasts suggested that the 677T allele is more likely to affect CRC in a recessive genetic model worldwide (P<0.0001, OR=0.86; 95% CI 0.76-0.96, P=0.06) and in Asians (P=0.0005, OR=0.75; 95% CI 0.64-0.88, P=0.71). Similarly, we found a significantly decreased risk of CRC for 1298C polymorphism (4,764 CRC patients and 6,592 controls) for a recessive genetic model worldwide (P=0.005, OR=0.81; 95% CI 0.70-0.94, P=0.40) and in Caucasians (P=0.04, OR=0.75 95% CI 0.57-0.99, P=0.35). No evidence of association of C677T (4,616 patients and 6,338 controls) and A1298C (1,272 patients and 1,684 controls) with colorectal adenoma were found. The evidence accumulated suggests that MTHFR may represent a low-penetrance susceptible gene for CRC, and that the two polymorphisms might protect against colorectal adenoma developing into cancer. A larger single study is required to further evaluate gene-gene and gene-environment interactions for MTHFR polymorphisms and the cancer risk in a specific population.

Original languageEnglish (US)
Pages (from-to)73-85
Number of pages13
JournalJournal of Human Genetics
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Adenoma
Meta-Analysis
Colorectal Neoplasms
Odds Ratio
Confidence Intervals
Genetic Models
Alleles
Genes
Gene-Environment Interaction
Penetrance
Population
Neoplasms

Keywords

  • Colorectal adenoma
  • Colorectal cancer
  • Meta-analysis
  • MTHFR
  • Polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer : A meta-analysis. / Huang, Yan; Han, Shizhong; Li, Yao; Mao, Yumin; Xie, Yi.

In: Journal of Human Genetics, Vol. 52, No. 1, 01.01.2007, p. 73-85.

Research output: Contribution to journalArticle

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abstract = "Association studies on the MTHFR polymorphisms (C677T and A1298C) in colorectal cancer (CRC) and colorectal adenoma have shown conflicting results. We performed a meta-analysis to better assess the purported associations. Overall, the 677T allele (10,131 patients and 15,362 controls) showed a small but significant protective effect against CRC compared to the 677C allele [P=0.0003, odds ratio (OR)=0.93; 95{\%} confidence interval (CI) 0.89-0.98, P=0.22 (for heterogeneity)] for a worldwide population. Meta-analyses of other genetic contrasts suggested that the 677T allele is more likely to affect CRC in a recessive genetic model worldwide (P<0.0001, OR=0.86; 95{\%} CI 0.76-0.96, P=0.06) and in Asians (P=0.0005, OR=0.75; 95{\%} CI 0.64-0.88, P=0.71). Similarly, we found a significantly decreased risk of CRC for 1298C polymorphism (4,764 CRC patients and 6,592 controls) for a recessive genetic model worldwide (P=0.005, OR=0.81; 95{\%} CI 0.70-0.94, P=0.40) and in Caucasians (P=0.04, OR=0.75 95{\%} CI 0.57-0.99, P=0.35). No evidence of association of C677T (4,616 patients and 6,338 controls) and A1298C (1,272 patients and 1,684 controls) with colorectal adenoma were found. The evidence accumulated suggests that MTHFR may represent a low-penetrance susceptible gene for CRC, and that the two polymorphisms might protect against colorectal adenoma developing into cancer. A larger single study is required to further evaluate gene-gene and gene-environment interactions for MTHFR polymorphisms and the cancer risk in a specific population.",
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