Different mouse thyroglobulins in the induction of experimental autoimmune thyroiditis

N. R. Rose, V. Tomazic

Research output: Contribution to journalArticle

Abstract

To detect differences in antigenic determinants of thyroglobulins (Tg) from different strains of mice Tg's were isolated from two congenic strains B10.D2 (H 2(d) and B10.Br (H 2(k)). The latter strain is much more susceptible to experimentally induced autoimmune thyroiditis than the former. Using B10.D2 Tg in complete Freund's adjuvant (CFA), mice of strains B10.D2, B10.Br, DBA (H 2(d)), and C57Br (H 2(k)) were immunized. All animals were given 2 weekly injections, killed 4 wk later and pathology indices (PI) determined. Both of the H 2(d) strains developed only minimal thyroiditis when immunized with B10.D2 Tg and moderate disease when immunized with B10.Br Tg. H 2(k) mice developed severe thyroiditis following immunization with B10.Br Tg and had a significantly lower PI with B10.D2 Tg. It was concluded that the immunogenicity of mouse Tg is linked to H 2.

Original languageEnglish (US)
Pages (from-to)4140
Number of pages1
JournalFederation proceedings
Volume34
Issue number3
StatePublished - 1975
Externally publishedYes

Fingerprint

Autoimmune Thyroiditis
Thyroglobulin
Thyroiditis
Pathology
Freund's Adjuvant
Epitopes
Immunization
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Different mouse thyroglobulins in the induction of experimental autoimmune thyroiditis. / Rose, N. R.; Tomazic, V.

In: Federation proceedings, Vol. 34, No. 3, 1975, p. 4140.

Research output: Contribution to journalArticle

@article{b613617f3e8c474488ddb8cc5814cd4a,
title = "Different mouse thyroglobulins in the induction of experimental autoimmune thyroiditis",
abstract = "To detect differences in antigenic determinants of thyroglobulins (Tg) from different strains of mice Tg's were isolated from two congenic strains B10.D2 (H 2(d) and B10.Br (H 2(k)). The latter strain is much more susceptible to experimentally induced autoimmune thyroiditis than the former. Using B10.D2 Tg in complete Freund's adjuvant (CFA), mice of strains B10.D2, B10.Br, DBA (H 2(d)), and C57Br (H 2(k)) were immunized. All animals were given 2 weekly injections, killed 4 wk later and pathology indices (PI) determined. Both of the H 2(d) strains developed only minimal thyroiditis when immunized with B10.D2 Tg and moderate disease when immunized with B10.Br Tg. H 2(k) mice developed severe thyroiditis following immunization with B10.Br Tg and had a significantly lower PI with B10.D2 Tg. It was concluded that the immunogenicity of mouse Tg is linked to H 2.",
author = "Rose, {N. R.} and V. Tomazic",
year = "1975",
language = "English (US)",
volume = "34",
pages = "4140",
journal = "Federation proceedings",
issn = "0014-9446",
number = "3",

}

TY - JOUR

T1 - Different mouse thyroglobulins in the induction of experimental autoimmune thyroiditis

AU - Rose, N. R.

AU - Tomazic, V.

PY - 1975

Y1 - 1975

N2 - To detect differences in antigenic determinants of thyroglobulins (Tg) from different strains of mice Tg's were isolated from two congenic strains B10.D2 (H 2(d) and B10.Br (H 2(k)). The latter strain is much more susceptible to experimentally induced autoimmune thyroiditis than the former. Using B10.D2 Tg in complete Freund's adjuvant (CFA), mice of strains B10.D2, B10.Br, DBA (H 2(d)), and C57Br (H 2(k)) were immunized. All animals were given 2 weekly injections, killed 4 wk later and pathology indices (PI) determined. Both of the H 2(d) strains developed only minimal thyroiditis when immunized with B10.D2 Tg and moderate disease when immunized with B10.Br Tg. H 2(k) mice developed severe thyroiditis following immunization with B10.Br Tg and had a significantly lower PI with B10.D2 Tg. It was concluded that the immunogenicity of mouse Tg is linked to H 2.

AB - To detect differences in antigenic determinants of thyroglobulins (Tg) from different strains of mice Tg's were isolated from two congenic strains B10.D2 (H 2(d) and B10.Br (H 2(k)). The latter strain is much more susceptible to experimentally induced autoimmune thyroiditis than the former. Using B10.D2 Tg in complete Freund's adjuvant (CFA), mice of strains B10.D2, B10.Br, DBA (H 2(d)), and C57Br (H 2(k)) were immunized. All animals were given 2 weekly injections, killed 4 wk later and pathology indices (PI) determined. Both of the H 2(d) strains developed only minimal thyroiditis when immunized with B10.D2 Tg and moderate disease when immunized with B10.Br Tg. H 2(k) mice developed severe thyroiditis following immunization with B10.Br Tg and had a significantly lower PI with B10.D2 Tg. It was concluded that the immunogenicity of mouse Tg is linked to H 2.

UR - http://www.scopus.com/inward/record.url?scp=0016658529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016658529&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 4140

JO - Federation proceedings

JF - Federation proceedings

SN - 0014-9446

IS - 3

ER -