Different marrow cell number requirements for the haemopoietic colony formation and the cure of the W/Wv anemia

W. Wiktor-Jedrzejczak; C. Szczylik; P. Górnaś; S. J. Sharkis; A. Ahmed

doi:10.1007/BF01922761

Different marrow cell number requirements for the haemopoietic colony formation and the cure of the W/W^v anemia

W. Wiktor-Jedrzejczak, C. Szczylik, P. Górnaś, S. J. Sharkis, A. Ahmed

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The lowest cell number in the normal marrow transplant, which allows the cure of W/W^v anemia was found to be between 10⁴ and 10⁵. This exceeds by several times the lowest cell number necessary for the haemopoietic colony formation. Therefore, either the colony forming cell is not the haemopoietic stem cell but rather its progeny, or this cell requires an aid from some other cells to exert its activity.

Original language	English (US)
Pages (from-to)	546-547
Number of pages	2
Journal	Experientia
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/BF01922761
State	Published - Apr 1979

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "The lowest cell number in the normal marrow transplant, which allows the cure of W/Wv anemia was found to be between 104 and 105. This exceeds by several times the lowest cell number necessary for the haemopoietic colony formation. Therefore, either the colony forming cell is not the haemopoietic stem cell but rather its progeny, or this cell requires an aid from some other cells to exert its activity.",

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AU - Wiktor-Jedrzejczak, W.

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AU - Sharkis, S. J.

AU - Ahmed, A.

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AB - The lowest cell number in the normal marrow transplant, which allows the cure of W/Wv anemia was found to be between 104 and 105. This exceeds by several times the lowest cell number necessary for the haemopoietic colony formation. Therefore, either the colony forming cell is not the haemopoietic stem cell but rather its progeny, or this cell requires an aid from some other cells to exert its activity.

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Different marrow cell number requirements for the haemopoietic colony formation and the cure of the W/W^v anemia

Abstract

ASJC Scopus subject areas

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