Different components of conditioned food aversion memory

Vladimir P. Nikitin, Svetlana V. Solntseva, Sergey A. Kozyrev, Pavel V. Nikitin, Alexey Shevelkin

Research output: Contribution to journalArticle

Abstract

Memory reconsolidation processes and protein kinase Mzeta (PKMzeta) activity in memory maintenance and reorganization are poorly understood. Therefore, we examined memory reconsolidation and PKMzeta activity during the maintenance and reorganization of a conditioned food aversion memory among snails. These processes were specifically evaluated after administration of a serotonin receptor antagonist (methiothepin), NMDA glutamate receptor antagonist (MK-801), protein synthesis inhibitor (cycloheximide; CYH), or PKMzeta inhibitor (zeta inhibitory peptide; ZIP) either 2 or 10 days after aversion training. Two days post-training, injections of MK-801 or CYH, combined with a conditioned stimulus reminder, caused amnesia development, and a second training 11 days after this induction did not lead to long-term memory formation. Interestingly, MK-801 or CYH injections and the reminder 10 days after training did not affect memory retrieval. Methiothepin and the reminder, or ZIP without the reminder, at 2 and 10 days after training led to memory impairment, while a second training 11 days after amnesia induction resulted in memory formation. These results suggest that the maintenance of a conditioned food aversion involves two different components with variable dynamics. One component could be characterized by memory strengthening over time and involve N-methyl-D-aspartate receptors and protein synthesis reconsolidation at early, but not late, training stages. The other memory component could involve serotonin-dependent reconsolidation and Mzeta-like kinase activity at both early and late stages after learning. Deficiencies within these two components led to various forms of memory impairment, which differed in terms of the formation of a conditioned food aversion during the second training.

Original languageEnglish (US)
Pages (from-to)104-113
Number of pages10
JournalBrain Research
Volume1642
DOIs
StatePublished - Jul 1 2016

Fingerprint

Food
Dizocilpine Maleate
Methiothepin
Amnesia
Maintenance
N-Methyl-D-Aspartate Receptors
Protein Kinases
Excitatory Amino Acid Antagonists
Serotonin Antagonists
Injections
Protein Synthesis Inhibitors
Long-Term Memory
Snails
Cycloheximide
Protein Kinase Inhibitors
Serotonin
Phosphotransferases
Learning
Proteins

Keywords

  • Memory reconsolidation
  • Memory reorganization
  • Mzeta protein kinase
  • Neurotransmitter receptors
  • Protein synthesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Nikitin, V. P., Solntseva, S. V., Kozyrev, S. A., Nikitin, P. V., & Shevelkin, A. (2016). Different components of conditioned food aversion memory. Brain Research, 1642, 104-113. https://doi.org/10.1016/j.brainres.2016.03.017

Different components of conditioned food aversion memory. / Nikitin, Vladimir P.; Solntseva, Svetlana V.; Kozyrev, Sergey A.; Nikitin, Pavel V.; Shevelkin, Alexey.

In: Brain Research, Vol. 1642, 01.07.2016, p. 104-113.

Research output: Contribution to journalArticle

Nikitin, VP, Solntseva, SV, Kozyrev, SA, Nikitin, PV & Shevelkin, A 2016, 'Different components of conditioned food aversion memory', Brain Research, vol. 1642, pp. 104-113. https://doi.org/10.1016/j.brainres.2016.03.017
Nikitin, Vladimir P. ; Solntseva, Svetlana V. ; Kozyrev, Sergey A. ; Nikitin, Pavel V. ; Shevelkin, Alexey. / Different components of conditioned food aversion memory. In: Brain Research. 2016 ; Vol. 1642. pp. 104-113.
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