TY - JOUR
T1 - Differences that matter
T2 - Major cytotoxic T cell-stimulating minor histocompatibility antigens
AU - Malarkannan, Subramaniam
AU - Horng, Tiffany
AU - Eden, Peter
AU - Gonzalez, Federico
AU - Shih, Patty
AU - Brouwenstijn, Nathalie
AU - Klinge, Heiko
AU - Christianson, Greg
AU - Roopenian, Derry
AU - Shastri, Nilabh
N1 - Funding Information:
This research was supported by National Institutes of Health grants (to N. S. and D. C. R.). S. M. was supported in part by the University of California Cancer Research Coordination Committee, P. A. E. by a National Institutes of Health training postdoctoral fellowship, T. H. by the Beckman undergraduate scholarship, and T. H. and P. S. by the Howard Hughes Medical Institute Undergraduate Biology Fellows Program. N. B. was supported by the Dutch Cancer Society and by a postdoctoral fellowship award made possible by the Wheeler Fund for the Biological Sciences at the University of California, Berkeley.
PY - 2000
Y1 - 2000
N2 - Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.
AB - Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.
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U2 - 10.1016/S1074-7613(00)00033-9
DO - 10.1016/S1074-7613(00)00033-9
M3 - Article
C2 - 11021531
AN - SCOPUS:0033662243
SN - 1074-7613
VL - 13
SP - 333
EP - 344
JO - Immunity
JF - Immunity
IS - 3
ER -