Differences that matter: Major cytotoxic T cell-stimulating minor histocompatibility antigens

Subramaniam Malarkannan, Tiffany Horng, Peter Eden, Federico Gonzalez, Patty Shih, Nathalie Brouwenstijn, Heiko Klinge, Greg Christianson, Derry Roopenian, Nilabh Shastri

Research output: Contribution to journalArticlepeer-review

Abstract

Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalImmunity
Volume13
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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