Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status

Edwin J. Asturias, Carlos Mayorga, Carlo Caffaro, Patricia Ramirez, Malathi Ram, Thomas Verstraeten, Ralf Clemens, Neal A Halsey

Research output: Contribution to journalArticle

Abstract

Ladino and native Indian Guatemalan infants developed high rates (96-100%) of protective antibodies after receiving conjugate Haemophilus influenzae type b and hepatitis B vaccines at 2, 4 and 6 months of age. Native Indian infants developed significantly (p <0.01) higher geometric mean anti-PRP (polyribose-ribitol-phosphate) and anti-HBs (anti-hepatitis b surface) antibody concentrations than Ladino infants. Malnourished infants generally responded as well as healthy infants. Unvaccinated native Indian infants had higher rates of developing anti-PRP antibodies than Ladino infants by seven months of age.

Original languageEnglish (US)
Pages (from-to)3650-3654
Number of pages5
JournalVaccine
Volume27
Issue number27
DOIs
StatePublished - Jun 2 2009

Fingerprint

Haemophilus Vaccines
Haemophilus influenzae type b
Haemophilus influenzae
hepatitis B
nationalities and ethnic groups
Nutritional Status
Hepatitis B
Ethnic Groups
nutritional status
immune response
vaccines
antibodies
hepatitis
infants
phosphates
Hepatitis B Vaccines
Antibodies
Hepatitis
Anti-Idiotypic Antibodies

Keywords

  • Haemophilus influenzae type b vaccine
  • Hepatitis B vaccine
  • Malnutrition

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status. / Asturias, Edwin J.; Mayorga, Carlos; Caffaro, Carlo; Ramirez, Patricia; Ram, Malathi; Verstraeten, Thomas; Clemens, Ralf; Halsey, Neal A.

In: Vaccine, Vol. 27, No. 27, 02.06.2009, p. 3650-3654.

Research output: Contribution to journalArticle

Asturias, Edwin J. ; Mayorga, Carlos ; Caffaro, Carlo ; Ramirez, Patricia ; Ram, Malathi ; Verstraeten, Thomas ; Clemens, Ralf ; Halsey, Neal A. / Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status. In: Vaccine. 2009 ; Vol. 27, No. 27. pp. 3650-3654.
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