Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status

Edwin J. Asturias, Carlos Mayorga, Carlo Caffaro, Patricia Ramirez, Malathi Ram, Thomas Verstraeten, Ralf Clemens, Neal A. Halsey

Research output: Contribution to journalArticle

Abstract

Ladino and native Indian Guatemalan infants developed high rates (96-100%) of protective antibodies after receiving conjugate Haemophilus influenzae type b and hepatitis B vaccines at 2, 4 and 6 months of age. Native Indian infants developed significantly (p < 0.01) higher geometric mean anti-PRP (polyribose-ribitol-phosphate) and anti-HBs (anti-hepatitis b surface) antibody concentrations than Ladino infants. Malnourished infants generally responded as well as healthy infants. Unvaccinated native Indian infants had higher rates of developing anti-PRP antibodies than Ladino infants by seven months of age.

Original languageEnglish (US)
Pages (from-to)3650-3654
Number of pages5
JournalVaccine
Volume27
Issue number27
DOIs
StatePublished - Jun 2 2009

Keywords

  • Haemophilus influenzae type b vaccine
  • Hepatitis B vaccine
  • Malnutrition

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status'. Together they form a unique fingerprint.

  • Cite this