Differences in the frequency of X-linked deleterious genes in human populations

A. Chakravarti, S. J. Bale

Research output: Contribution to journalArticle

Abstract

Hunter disease, an X-linked recessive lethal, has recently been observed to occur in high frequency in Israeli Jews as compared with other Caucasian populations. Using the equilibrium distribution of the number of affected males, one can compute the probability that the excess frequency is due to genetic drift. Our results demonstrate that the elevated frequency of Hunter disease is compatible with drift.

Original languageEnglish (US)
Pages (from-to)1252-1257
Number of pages6
JournalAmerican journal of human genetics
Volume35
Issue number6
StatePublished - Dec 1 1983

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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