Differences in the effects of hypercapnia and hypoxia on the swallowing reflex in cats

T. Nishino, T. Kohchi, Y. Honda, M. Shirahata, T. Yonezawa

Research output: Contribution to journalArticle

Abstract

The effects of changes in PaCO2 and PaO2 on the swallowing reflex were studied in anaesthetized, vagotomized, paralysed and artificially ventilated cats. The swallowing reflex was induced by electrical stimulation of the superior laryngeal nerve (SLN). This initially suppressed activity in the phrenic nerve (PN). The swallowing reflex was then identified by a characteristic brief burst of PN activity and a large amplitude burst of hypoglossal nerve (HN) activity. Steady-state responses to constant SLN stimulation for 60 s were measured at four carbon dioxide tensions (PaCO2 3.9, 5.1, 6.3 and 7.8 kPa) with hyperoxia (PaCO2 > 51 kPa) and at four values of PaO2 (PaO2 56, 11.3, 6.9 and 4.8 kPa) at a fixed PaCO2 (PaCO2 4.2 kPa). Although both hypercapnia and hypoxia increased the spontaneous respiratory activity in PN and HN, the number of swallows elicited during SLN stimulation was not influenced by PaCO2′, whereas a progressive decrease in the number of swallows with decreasing PaO2 was observed consistently. These results indicate that the swallowing reflex is independent of the background respiratory activity and that hypoxia depresses the swallowing reflex, whereas hypercapnia has no effect.

Original languageEnglish (US)
Pages (from-to)903-908
Number of pages6
JournalBritish Journal of Anaesthesia
Volume58
Issue number8
DOIs
StatePublished - Aug 1986
Externally publishedYes

Fingerprint

Hypoxia
hypercapnia
Hypercapnia
Deglutition
Nerve
reflexes
Reflex
hypoxia
Laryngeal Nerves
Carbon dioxide
nerve tissue
Cats
Phrenic Nerve
cats
Hypoglossal Nerve
Swallows
Burst
Hyperoxia
Carbon Dioxide
Electric Stimulation

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Differences in the effects of hypercapnia and hypoxia on the swallowing reflex in cats. / Nishino, T.; Kohchi, T.; Honda, Y.; Shirahata, M.; Yonezawa, T.

In: British Journal of Anaesthesia, Vol. 58, No. 8, 08.1986, p. 903-908.

Research output: Contribution to journalArticle

Nishino, T. ; Kohchi, T. ; Honda, Y. ; Shirahata, M. ; Yonezawa, T. / Differences in the effects of hypercapnia and hypoxia on the swallowing reflex in cats. In: British Journal of Anaesthesia. 1986 ; Vol. 58, No. 8. pp. 903-908.
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