Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives

Shashwath A. Meda, Adrienne Gill, Michael C. Stevens, Raymond P. Lorenzoni, David C. Glahn, Vince Daniel Calhoun, John A. Sweeney, Carol A. Tamminga, Matcheri S. Keshavan, Gunvant Thaker, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Background: Schizophrenia and bipolar disorder share overlapping symptoms and genetic etiology. Functional brain dysconnectivity is seen in both disorders. Methods: We compared 70 schizophrenia and 64 psychotic bipolar probands, their respective unaffected first-degree relatives (n = 70, and n = 52), and 118 healthy subjects, all group age-, gender-, and ethnicity-matched. We used functional network connectivity analysis to measure differential connectivity among 16 functional magnetic resonance imaging resting state networks. First, we examined connectivity differences between probands and control subjects. Next, we probed these dysfunctional connections in relatives for potential endophenotypes. Network connectivity was then correlated with Positive and Negative Syndrome Scale (PANSS) scores to reveal clinical relationships. Results: Three different network pairs were differentially connected in probands (false-discovery rate corrected q

Original languageEnglish (US)
Pages (from-to)881-889
Number of pages9
JournalBiological Psychiatry
Volume71
Issue number10
DOIs
StatePublished - May 15 2012
Externally publishedYes

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Schizophrenia
Magnetic Resonance Imaging
Endophenotypes
Bipolar Disorder
Healthy Volunteers
Age Groups
Brain

Keywords

  • Bipolar
  • default mode
  • functional connectivity
  • gene
  • relatives
  • resting state
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives. / Meda, Shashwath A.; Gill, Adrienne; Stevens, Michael C.; Lorenzoni, Raymond P.; Glahn, David C.; Calhoun, Vince Daniel; Sweeney, John A.; Tamminga, Carol A.; Keshavan, Matcheri S.; Thaker, Gunvant; Pearlson, Godfrey D.

In: Biological Psychiatry, Vol. 71, No. 10, 15.05.2012, p. 881-889.

Research output: Contribution to journalArticle

Meda, Shashwath A. ; Gill, Adrienne ; Stevens, Michael C. ; Lorenzoni, Raymond P. ; Glahn, David C. ; Calhoun, Vince Daniel ; Sweeney, John A. ; Tamminga, Carol A. ; Keshavan, Matcheri S. ; Thaker, Gunvant ; Pearlson, Godfrey D. / Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives. In: Biological Psychiatry. 2012 ; Vol. 71, No. 10. pp. 881-889.
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AU - Lorenzoni, Raymond P.

AU - Glahn, David C.

AU - Calhoun, Vince Daniel

AU - Sweeney, John A.

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KW - default mode

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KW - relatives

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