Abstract
A composite measure of subclinical vascular disease has been developed in the Cardiovascular Health Study (CHS). In previous reports, we measured the prevalence of subclinical disease among the original 5201 participants in the CHS, the relationship of risk factors to subclinical disease, and the association of subclinical disease to clinical coronary heart disease. In 1992 to 1993 (year 4 of the study), a larger cohort of 424 black women and 248 black men was added to the study. In this study, we have compared the prevalence of subclinical disease among blacks and whites in the CHS and the association with cardiovascular risk factors. The prevalence of subclinical disease for all participants (aged ≤65 years) was 41.3% for white women, 39.7% for black women, 41.9% for white men, and 43.7% for black men. The prevalence increased with age. The risk factor association for subclinical disease were similar among blacks and whites. In multivariate analysis, age, systolic blood pressure, LDL cholesterol, smoking, and family history of myocardial infarction were independently associated with subclinical disease among both black and white women, while for white men, systolic blood pressure, use of antihypertensive medication, smoking, body mass index, and diastolic blood pressure (reverse) were related to subclinical disease. In black men, blood triglyceride level, use of antihypertensive medications, and family history of myocardial infarction (inverse) were associated with subclinical disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-293 |
| Number of pages | 11 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 18 |
| Issue number | 2 |
| State | Published - 1998 |
Fingerprint
Keywords
- Cardiovascular disease
- Race
- Risk factors
- Subclinical disease
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Differences in prevalence of and risk factors for subclinical vascular disease among black and white participants in the cardiovascular health study. / Kuller, Lewis; Fisher, Lloyd; McClelland, Robyn; Fried, Linda P; Cushman, Mary; Jackson, Sharon; Manolio, Teri.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 18, No. 2, 1998, p. 283-293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences in prevalence of and risk factors for subclinical vascular disease among black and white participants in the cardiovascular health study
AU - Kuller, Lewis
AU - Fisher, Lloyd
AU - McClelland, Robyn
AU - Fried, Linda P
AU - Cushman, Mary
AU - Jackson, Sharon
AU - Manolio, Teri
PY - 1998
Y1 - 1998
N2 - A composite measure of subclinical vascular disease has been developed in the Cardiovascular Health Study (CHS). In previous reports, we measured the prevalence of subclinical disease among the original 5201 participants in the CHS, the relationship of risk factors to subclinical disease, and the association of subclinical disease to clinical coronary heart disease. In 1992 to 1993 (year 4 of the study), a larger cohort of 424 black women and 248 black men was added to the study. In this study, we have compared the prevalence of subclinical disease among blacks and whites in the CHS and the association with cardiovascular risk factors. The prevalence of subclinical disease for all participants (aged ≤65 years) was 41.3% for white women, 39.7% for black women, 41.9% for white men, and 43.7% for black men. The prevalence increased with age. The risk factor association for subclinical disease were similar among blacks and whites. In multivariate analysis, age, systolic blood pressure, LDL cholesterol, smoking, and family history of myocardial infarction were independently associated with subclinical disease among both black and white women, while for white men, systolic blood pressure, use of antihypertensive medication, smoking, body mass index, and diastolic blood pressure (reverse) were related to subclinical disease. In black men, blood triglyceride level, use of antihypertensive medications, and family history of myocardial infarction (inverse) were associated with subclinical disease.
AB - A composite measure of subclinical vascular disease has been developed in the Cardiovascular Health Study (CHS). In previous reports, we measured the prevalence of subclinical disease among the original 5201 participants in the CHS, the relationship of risk factors to subclinical disease, and the association of subclinical disease to clinical coronary heart disease. In 1992 to 1993 (year 4 of the study), a larger cohort of 424 black women and 248 black men was added to the study. In this study, we have compared the prevalence of subclinical disease among blacks and whites in the CHS and the association with cardiovascular risk factors. The prevalence of subclinical disease for all participants (aged ≤65 years) was 41.3% for white women, 39.7% for black women, 41.9% for white men, and 43.7% for black men. The prevalence increased with age. The risk factor association for subclinical disease were similar among blacks and whites. In multivariate analysis, age, systolic blood pressure, LDL cholesterol, smoking, and family history of myocardial infarction were independently associated with subclinical disease among both black and white women, while for white men, systolic blood pressure, use of antihypertensive medication, smoking, body mass index, and diastolic blood pressure (reverse) were related to subclinical disease. In black men, blood triglyceride level, use of antihypertensive medications, and family history of myocardial infarction (inverse) were associated with subclinical disease.
KW - Cardiovascular disease
KW - Race
KW - Risk factors
KW - Subclinical disease
UR - http://www.scopus.com/inward/record.url?scp=0031809188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031809188&partnerID=8YFLogxK
M3 - Article
VL - 18
SP - 283
EP - 293
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 2
ER -