@article{2c2faa6cdce8467cad7e1c14c7f8e0b1,
title = "Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients",
abstract = "Purpose: To compare patient/tumor characteristics and outcomes of Asians to Caucasian patients with epithelial ovarian cancer. Methods: Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic features, disease-specific and all-cause survival were analyzed. Results: Of 7914 patients, 7641 were Caucasian and 273 Asian. When compared to Caucasians, Asians were younger at trial enrollment, had a better performance status, earlier-stage cancers (17.2% vs. 8.1% with stage I; p < 0.001), and were more likely to be of clear cell (15.8% vs. 6.2%, p < 0.001) and mucinous (3.3% vs. 1.9%, p < 0.001) histology. Asians had an improved 5-year disease-specific survival of 54.1% compared to 46.1% for Caucasians, p = 0.001. In multivariate analysis, the Asian race remained a significant prognostic factor for all-cause survival (HR: 0.84; 95% CI: 0.72–0.99; p = 0.04). Other factors predictive of improved survival included younger age, better performance status, optimal cytoreduction, earlier stage, non-clear cell histology, and lower grade tumors. Conclusion: Asians enrolled into phase III ovarian cancer clinical trials were younger, with better performance status, earlier-stage of disease, and have a greater number of clear cell and mucinous tumors. After adjusting for these prognostic factors, Asians have a better survival compared to Caucasians.",
keywords = "Bevacizumab, Body mass index, Clear cell, Pharmacogenomics, Racial differences, Survival outcomes",
author = "Fuh, {Katherine C.} and Java, {James J.} and Chan, {John K.} and Kapp, {Daniel S.} and Monk, {Bradley J.} and Burger, {Robert A.} and Young, {Robert C.} and Alberts, {David S.} and McGuire, {William P.} and Maurie Markman and Jeffrey Bell and Ozols, {Robert F.} and Armstrong, {Deborah K.} and C. Aghajanian and Bookman, {Michael A.} and Mannel, {Robert S.}",
note = "Funding Information: This work supported by National Cancer Institute grants to Gynecologic Oncology Group Administrative Office ( CA-27469 ), GOG Statistical Office ( CA-37517 ), NRG Oncology ( U10 CA 180822 ), NRG Operations ( U10 CA180868 ) and UG1CA189867 ( NCORP ). Funding Information: This work supported by National Cancer Institute grants to Gynecologic Oncology Group Administrative Office (CA-27469), GOG Statistical Office (CA-37517), NRG Oncology (U10 CA 180822), NRG Operations (U10 CA180868) and UG1CA189867 (NCORP). The following Gynecologic Oncology Group member institutions participated in the primary treatment studies: Ohio State University Comprehensive Cancer Center, University of Oklahoma Health Sciences Center, University of Minnesota Medical Center ? Fairview, University of California Medical Center at Irvine ? Orange Campus, University of Iowa Hospitals and Clinics, Duke University Medical Center, Washington University School of Medicine, Indiana University Hospital/Melvin and Bren Simon Cancer Center, Abington Memorial Hospital, Fred Hutchinson Cancer Research Center, University of North Carolina at Chapel Hill, Southwest Oncology Group, Walter Reed National Military Medical Center, Tacoma General Hospital, Mayo Clinic, Moffitt Cancer Center and Research Institute, Cleveland Clinic Foundation, Australia New Zealand Gynaecological, University of Colorado Cancer Center ? Anschutz Cancer Pavilion, Cancer Trials Support Unit, Wake Forest University Health Sciences, University of Kentucky, University of Mississippi Medical Center, University of Alabama at Birmingham, Abramson Cancer Center of the University of Pennsylvania, Rush University Medical Center, M D Anderson Cancer Center, Tufts-New England Medical Center, Women's Cancer Center of Nevada, Stony Brook University Medical Center, Gynecologic Oncology Network/Brody School of Medicine, Penn State Milton S Hershey Medical Center, University of Massachusetts Memorial Health Care, Fox Chase Cancer Center, University of Cincinnati, Case Western Reserve University, Cooper Hospital University Medical Center, Roswell Park Cancer Institute, University of California at Los Angeles Health System, Thomas Jefferson University Hospital, Saitama Medical University International Medical Center, North Shore University Hospital, University of Chicago, Yale University, Community Clinical Oncology Program, University of Virginia, Albany Medical College, Metro-Minnesota CCOP, Johns Hopkins Oncology Center, Oregon Health Sciences University, Wayne State University/Karmanos Cancer Institute, University of Rochester Medical Center, University of Wisconsin Hospital and Clinics, Georgetown University Hospital, Eastern Pennsylvania GYN/ONC Center PC, Seoul National University Hospital, Medical University of South Carolina, University of Miami School of Medicine, Memorial Sloan Kettering Cancer Center, Ellis Fischel Cancer Center, Fletcher Allen Health Care, Cancer Research for the Ozarks NCORP, University of Pittsburgh Cancer Institute (UPCI), The Hospital of Central Connecticut, Stanford University Medical Center, Women and Infants Hospital, University of Hawaii, State University of New York at Syracuse, University of New Mexico, Michigan Cancer Research Consortium Community Clinical Oncology Program, Mount Sinai School of Medicine, Northern Indiana Cancer Research Consortium, Eastern Virginia Medical School, Northwestern University, University of Arizona, University of Texas ? Galveston, Cancer Research Consortium of West Michigan NCORP, University of South California, ECOG Statistical Center, Long Island Jewish Medical Center, Saint Vincent Hospital, State University of New York Downstate Medical Center, North Central Cancer Treatment Group, Georgia Center for Oncology Research and Education (CORE), Scott and White Memorial Hospital, Wisconsin NCI Community Oncology Research Program, Missouri Valley Cancer Consortium CCOP, Carle Cancer Center, Gynecologic Oncology of West Michigan PLLC, Central Illinois CCOP, Delaware/Christiana Care CCOP, Virginia Commonwealth University, Emory University Clinic, Kansas City CCOP, Kalamazoo CCOP, Southeast Gynecologic Oncology Associates, Evanston CCOP-NorthShore University Health System, Northern New Jersey CCOP, Virginia Mason CCOP, Western Regional CCOP, William Beaumont Hospital, Colorado Cancer Research Program NCORP, Saint Louis-Cape Girardeau CCOP, New York University Medical Center, Geisinger Medical Center, LDS Hospital, Aurora Women's Pavilion of Aurora West Allis Medical Center, University of Illinois, Columbia River Oncology Program, Upstate Carolina CCOP, Dayton Clinical Oncology Program, Mainline Health CCOP, Heartland Cancer Research CCOP and Wichita CCOP. NCT00262847; NCT00006096; NCT00003644; NCT00003322. Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = aug,
doi = "10.1016/j.ygyno.2019.05.013",
language = "English (US)",
volume = "154",
pages = "420--425",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",
}