Differences in ornithine decarboxylase and androgen receptor allele frequences among ethnic groups

Thomas G. O'Brien, Y. Guo, K. Visvanathan, J. Sciulli, M. McLaine, K. J. Helzlsouer, D. Watkins-Bruner

Research output: Contribution to journalArticlepeer-review

Abstract

Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer. ODC is a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determined ODC allele frequencies and distribution of AR alleles in American Caucasians, African-Americans, Hispanics, Europeans, and Africans. The frequency of the ODC A allele varied from 0.183 (Hispanics, Europeans) to 0.415 (Africans) with American Caucasian and African-Americans having intermediate values. The mean number of CAG repeats in the AR gene varied from 19.8 (African-Americans) to 25.1 (Hispanics). It is possible that ethnic differences in risk alleles for ODC and AR may account for some of the ethnic variation in prostate cancer risk.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalMolecular Carcinogenesis
Volume41
Issue number2
DOIs
StatePublished - Oct 1 2004

Keywords

  • Cancer susceptibility
  • Gene polymorphisms
  • Prostate cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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