Differences in genotypes of Helicobacter pylori from different human populations

Dangeruta Kersulyte, Asish K. Mukhopadhyay, Billie Velapatiño, Wanwen Su, Zhijun Pan, Claudia Garcia, Virginia Hernandez, Yanet Valdez, Rajesh S. Mistry, Robert H Gilman, Yuan Yuan, Hua Gao, Teresa Alarcón, Manuel López-Brea, G. Balakrish Nair, Abhijit Chowdhury, Simanti Datta, Mutsunori Shirai, Teruko Nakazawa, Reidwaan AllyIsidore Segal, Benjamin C Y Wong, S. K. Lam, Farzad O. Olfat, Thomas Borén, Lars Engstrand, Olga Torres, Roberto Schneider, Julian E. Thomas, Steven Czinn, Douglas E. Berg

Research output: Contribution to journalArticle

Abstract

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric pathogen. Five types of deletion, insertion, and substitution motifs were found at the right end of the H. pylori cag pathogenicity island. Of the three most common motifs, type I predominated in Spaniards, native Peruvians, and Guatemalan Ladinos (mixed Amerindian-European ancestry) and also in native Africans and U.S. residents; type II predominated among Japanese and Chinese; and type III predominated in Indians from Calcutta. Sequences in the cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native Peruvians were also more like those from Spaniards than those from Asians. These indications of relatedness of Latin American and Spanish strains, despite the closer genetic relatedness of Amerindian and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about 500 years ago. This thinking, in turn, suggests that H. pylori infection might have become widespread in people quite recently in human evolution.

Original languageEnglish (US)
Pages (from-to)3210-3218
Number of pages9
JournalJournal of Bacteriology
Volume182
Issue number11
DOIs
StatePublished - Jun 2000
Externally publishedYes

Fingerprint

Helicobacter pylori
Genotype
Population Groups
Population
Genomic Islands
Nucleotide Motifs
Cytotoxins
Helicobacter Infections
Hispanic Americans
Genes
Stomach
Alleles
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Kersulyte, D., Mukhopadhyay, A. K., Velapatiño, B., Su, W., Pan, Z., Garcia, C., ... Berg, D. E. (2000). Differences in genotypes of Helicobacter pylori from different human populations. Journal of Bacteriology, 182(11), 3210-3218. https://doi.org/10.1128/JB.182.11.3210-3218.2000

Differences in genotypes of Helicobacter pylori from different human populations. / Kersulyte, Dangeruta; Mukhopadhyay, Asish K.; Velapatiño, Billie; Su, Wanwen; Pan, Zhijun; Garcia, Claudia; Hernandez, Virginia; Valdez, Yanet; Mistry, Rajesh S.; Gilman, Robert H; Yuan, Yuan; Gao, Hua; Alarcón, Teresa; López-Brea, Manuel; Nair, G. Balakrish; Chowdhury, Abhijit; Datta, Simanti; Shirai, Mutsunori; Nakazawa, Teruko; Ally, Reidwaan; Segal, Isidore; Wong, Benjamin C Y; Lam, S. K.; Olfat, Farzad O.; Borén, Thomas; Engstrand, Lars; Torres, Olga; Schneider, Roberto; Thomas, Julian E.; Czinn, Steven; Berg, Douglas E.

In: Journal of Bacteriology, Vol. 182, No. 11, 06.2000, p. 3210-3218.

Research output: Contribution to journalArticle

Kersulyte, D, Mukhopadhyay, AK, Velapatiño, B, Su, W, Pan, Z, Garcia, C, Hernandez, V, Valdez, Y, Mistry, RS, Gilman, RH, Yuan, Y, Gao, H, Alarcón, T, López-Brea, M, Nair, GB, Chowdhury, A, Datta, S, Shirai, M, Nakazawa, T, Ally, R, Segal, I, Wong, BCY, Lam, SK, Olfat, FO, Borén, T, Engstrand, L, Torres, O, Schneider, R, Thomas, JE, Czinn, S & Berg, DE 2000, 'Differences in genotypes of Helicobacter pylori from different human populations', Journal of Bacteriology, vol. 182, no. 11, pp. 3210-3218. https://doi.org/10.1128/JB.182.11.3210-3218.2000
Kersulyte D, Mukhopadhyay AK, Velapatiño B, Su W, Pan Z, Garcia C et al. Differences in genotypes of Helicobacter pylori from different human populations. Journal of Bacteriology. 2000 Jun;182(11):3210-3218. https://doi.org/10.1128/JB.182.11.3210-3218.2000
Kersulyte, Dangeruta ; Mukhopadhyay, Asish K. ; Velapatiño, Billie ; Su, Wanwen ; Pan, Zhijun ; Garcia, Claudia ; Hernandez, Virginia ; Valdez, Yanet ; Mistry, Rajesh S. ; Gilman, Robert H ; Yuan, Yuan ; Gao, Hua ; Alarcón, Teresa ; López-Brea, Manuel ; Nair, G. Balakrish ; Chowdhury, Abhijit ; Datta, Simanti ; Shirai, Mutsunori ; Nakazawa, Teruko ; Ally, Reidwaan ; Segal, Isidore ; Wong, Benjamin C Y ; Lam, S. K. ; Olfat, Farzad O. ; Borén, Thomas ; Engstrand, Lars ; Torres, Olga ; Schneider, Roberto ; Thomas, Julian E. ; Czinn, Steven ; Berg, Douglas E. / Differences in genotypes of Helicobacter pylori from different human populations. In: Journal of Bacteriology. 2000 ; Vol. 182, No. 11. pp. 3210-3218.
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AU - Garcia, Claudia

AU - Hernandez, Virginia

AU - Valdez, Yanet

AU - Mistry, Rajesh S.

AU - Gilman, Robert H

AU - Yuan, Yuan

AU - Gao, Hua

AU - Alarcón, Teresa

AU - López-Brea, Manuel

AU - Nair, G. Balakrish

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AU - Shirai, Mutsunori

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