Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses

Shanmugam Saravanan, Selvamurthi Gomathi, Bagavathi Kausalya, Jayaseelan Boobalan, Kailapuri G. Murugavel, Pachamuthu Balakrishnan, Sarvode N. Mothi, Sunil S. Solomon, Nagalingeswaran Kumarasamy, Poongulali Selvamuthu, Suniti Solomon, Davey M. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

Original languageEnglish (US)
Pages (from-to)655-657
Number of pages3
JournalAIDS research and human retroviruses
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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