Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses

Shanmugam Saravanan; Selvamurthi Gomathi; Bagavathi Kausalya; Jayaseelan Boobalan; Kailapuri G. Murugavel; Pachamuthu Balakrishnan; Sarvode N. Mothi; Sunil S. Solomon; Nagalingeswaran Kumarasamy; Poongulali Selvamuthu; Suniti Solomon; Davey M. Smith

doi:10.1089/aid.2015.0023

Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses

Shanmugam Saravanan, Selvamurthi Gomathi, Bagavathi Kausalya, Jayaseelan Boobalan, Kailapuri G. Murugavel, Pachamuthu Balakrishnan, Sarvode N. Mothi, Sunil S. Solomon, Nagalingeswaran Kumarasamy, Poongulali Selvamuthu, Suniti Solomon, Davey M. Smith

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

Original language	English (US)
Pages (from-to)	655-657
Number of pages	3
Journal	AIDS research and human retroviruses
Volume	31
Issue number	6
DOIs	https://doi.org/10.1089/aid.2015.0023
State	Published - Jun 1 2015

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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Saravanan, S., Gomathi, S., Kausalya, B., Boobalan, J., Murugavel, K. G., Balakrishnan, P., Mothi, S. N., Solomon, S. S., Kumarasamy, N., Selvamuthu, P., Solomon, S., & Smith, D. M. (2015). Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses. AIDS research and human retroviruses, 31(6), 655-657. https://doi.org/10.1089/aid.2015.0023

Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses. / Saravanan, Shanmugam; Gomathi, Selvamurthi; Kausalya, Bagavathi et al.
In: AIDS research and human retroviruses, Vol. 31, No. 6, 01.06.2015, p. 655-657.

Research output: Contribution to journal › Article › peer-review

Saravanan, S, Gomathi, S, Kausalya, B, Boobalan, J, Murugavel, KG, Balakrishnan, P, Mothi, SN, Solomon, SS, Kumarasamy, N, Selvamuthu, P, Solomon, S & Smith, DM 2015, 'Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses', AIDS research and human retroviruses, vol. 31, no. 6, pp. 655-657. https://doi.org/10.1089/aid.2015.0023

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abstract = "In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.",

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AU - Boobalan, Jayaseelan

AU - Murugavel, Kailapuri G.

AU - Balakrishnan, Pachamuthu

AU - Mothi, Sarvode N.

AU - Solomon, Sunil S.

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Differences in evolution of HIV-1 subtype C reverse transcriptase between children and adults likely explained by maturity of cytotoxic T-lymphocyte responses

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