Abstract
Previous studies of a tau polymorphism in Caucasian subjects with progressive supranuclear palsy (PSP) showed an over-representation of one genotype, AO/AO, versus normal control subjects. This result suggested that tau may be playing a genetic role in the progression of PSP. This study examines whether the over-representation of AO/AO is Caucasian-specific or universal to PSP. Unfortunately, we found this dinucleotide repeat was relatively non-polymorphic in Japanese subjects. As a result, the genotypes were virtually the same, AO/AO, between Japanese PSP and control subjects. However, this outcome, albeit negative, does suggest two possible roles of the tau gene in PSP pathogenesis: (1) the role of this dinucleotide repeat in PSP may be different between Caucasian and Japanese populations or (2) this repeat may not be causal for PSP but represents a marker for other molecular genetic risk factors within or close to the tau gene on chromosome 17.
Original language | English (US) |
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Pages (from-to) | 135-137 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 250 |
Issue number | 2 |
DOIs | |
State | Published - Jun 19 1998 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Caucasian
- Chromosome 17
- Dinucleotide repeat
- Exon 10
- Intron
- Japanese
- Progressive supranuclear palsy
- Tau
ASJC Scopus subject areas
- General Neuroscience