Differences by Sex in Cardiovascular Comorbid Conditions among Older Adults (Aged 50-64 or ≥65 Years) Receiving Care for Human Immunodeficiency Virus

Emma L. Frazier, Madeline Y. Sutton, Yunfeng Tie, Jennifer Fagan, Robyn Neblett Fanfair

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Differences by sex in cardiovascular comorbid conditions among human immunodeficiency virus (HIV)-infected persons aged 50-64 years have been understudied; even fewer data are available for persons aged ≥65 years. Methods: We used matched interview and medical record abstraction data from the 2009-2012 data cycles of the Medical Monitoring Project, a nationally representative sample of HIV-infected adults in care. We included men and women aged 50-64 and ≥65 years at time of interview. We calculated weighted prevalence estimates and used logistic regression to compute adjusted prevalence differences and 95% confidence intervals (CIs) assessing sex differences in various characteristics and cardiovascular comorbid conditions. Comorbid conditions included overweight/obesity (body mass index ≥25), abnormal total cholesterol level (defined as ≥200 mg/dL), diagnosed diabetes mellitus, or diagnosed hypertension. Results: Of 7436 participants, 89.5% were aged 50-64 years and 10.4% aged ≥65 years, 75.1% were men, 40.4% (95% CI, 33.5%-47.2%) were non-Hispanic black, 72.0% (70.4%-73.6%) had HIV infection diagnosed ≥10 years earlier. After adjustment for sociodemographic and behavioral factors, women aged 50-64 years were more likely than men to be obese (adjusted prevalence difference, 8.4; 95% CI, 4.4-12.3), have hypertension (3.9;. 1-7.6), or have high total cholesterol levels (9.9; 6.2-13.6). Women aged ≥65 years had higher prevalences of diabetes mellitus and high total cholesterol levels than men. Conclusions: Cardiovascular comorbid conditions were prevalent among older HIV-infected persons in care; disparities existed by sex. Closer monitoring and risk-reduction strategies for cardiovascular comorbid conditions are warranted for older HIV-infected persons, especially older women.

Original languageEnglish (US)
Pages (from-to)2091-2100
Number of pages10
JournalClinical Infectious Diseases
Volume69
Issue number12
DOIs
StatePublished - Nov 27 2019

Keywords

  • HIV
  • aging
  • cardiovascular
  • comorbidity
  • sex differences

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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