Differences between Hispanic and non-Hispanic white women with breast cancer for clinical characteristics and their correlates

Avonne E. Connor, Richard N. Baumgartner, Dongyan Yang, Martha L. Slattery, Anna R. Giuliano, Betsy C. Risendal, Madiha M. Abdel-Maksoud, Kathy B. Baumgartner

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Body size and ethnicity may influence breast cancer tumor characteristics at diagnosis. We compared Hispanic and non-Hispanic white (NHW) cases for stage of disease, estrogen receptor (ER) status, tumor size, and lymph node status, and the associations of these with body size in the 4-Corners Breast Cancer Study. Methods: One thousand five hundred twenty-seven NHW and 798 Hispanic primary incident breast cancer cases diagnosed between October 1999 and May 2004 were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multiple logistic regression. Results: Hispanic women were more likely to have larger (>1 cm) ER- tumors and more than four positive lymph nodes (P < .003). Lymph node status was not associated with body size. However, among NHW women, obesity (body mass index >30) and increased waist circumference (>38.5 inches) were significantly positively associated with ER- tumor status (OR, 1.87; 95% CI, 1.24-2.81 and OR, 2.59; 95% CI, 1.58-4.22, respectively). In contrast, among Hispanic women, obesity and waist circumference had inverse associations with ER- tumor status (OR, 0.49; 95% CI, 0.29-0.84 and OR, 0.56; 95% CI, 0.30-1.05, respectively). Conclusions: Hispanic ethnicity may modify the association of body size and composition with ER- breast cancer. This finding could have relevance to clinical treatment and prognosis.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalAnnals of epidemiology
Volume23
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Keywords

  • Breast neoplasms
  • Hispanic Americans
  • Obesity

ASJC Scopus subject areas

  • Epidemiology

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