Differences between hereditary and sporadic ovarian cancer

R. P. Zweemer; R. H.M. Verheijen; F. H. Menko; J. J.P. Gille; Paulus Joannes van Diest; J. W. Coebergh; P. A. Shaw; I. J. Jacobs; P. Kenemans

doi:10.1016/S0301-2115(98)00218-8

Differences between hereditary and sporadic ovarian cancer

R. P. Zweemer, R. H.M. Verheijen, F. H. Menko, J. J.P. Gille, Paulus Joannes van Diest, J. W. Coebergh, P. A. Shaw, I. J. Jacobs, P. Kenemans

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	151-153
Number of pages	3
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/S0301-2115(98)00218-8
State	Published - Feb 1 1999
Externally published	Yes

Keywords

BRCA1
Hereditary
Molecular genetics
Ovarian cancer

ASJC Scopus subject areas

Obstetrics and Gynecology
Reproductive Medicine

Access to Document

10.1016/S0301-2115(98)00218-8

Cite this

@article{fc208e68ef4e4dd184df25a40c034e5a,

title = "Differences between hereditary and sporadic ovarian cancer",

abstract = "Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "BRCA1, Hereditary, Molecular genetics, Ovarian cancer",

author = "Zweemer, {R. P.} and Verheijen, {R. H.M.} and Menko, {F. H.} and Gille, {J. J.P.} and {van Diest}, {Paulus Joannes} and Coebergh, {J. W.} and Shaw, {P. A.} and Jacobs, {I. J.} and P. Kenemans",

year = "1999",

month = feb,

day = "1",

doi = "10.1016/S0301-2115(98)00218-8",

language = "English (US)",

volume = "82",

pages = "151--153",

journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Differences between hereditary and sporadic ovarian cancer

AU - Zweemer, R. P.

AU - Verheijen, R. H.M.

AU - Menko, F. H.

AU - Gille, J. J.P.

AU - van Diest, Paulus Joannes

AU - Coebergh, J. W.

AU - Shaw, P. A.

AU - Jacobs, I. J.

AU - Kenemans, P.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - BRCA1

KW - Hereditary

KW - Molecular genetics

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=0032972397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032972397&partnerID=8YFLogxK

U2 - 10.1016/S0301-2115(98)00218-8

DO - 10.1016/S0301-2115(98)00218-8

M3 - Article

C2 - 10206407

AN - SCOPUS:0032972397

SN - 0301-2115

VL - 82

SP - 151

EP - 153

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

IS - 2

ER -

Differences between hereditary and sporadic ovarian cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this