Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging

Ann Zenobia Moore, Giorgio Caturegli, E. Jeffrey Metter, Sokratis Makrogiannis, Susan M. Resnick, Tamara B. Harris, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Objectives To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality. Design Cross-sectional study. Setting Baltimore Longitudinal Study of Aging. Participants Seven hundred eighty-six individuals with a mean age of 66.3 (range 26-96) (N = 786). A sensitivity analysis was conducted in a subset of participants matched according to sex, muscle mass, and body size. Measurements Muscle quality was operationalized as the ratio of knee-extension strength (isokinetic dynamometry) to thigh muscle cross-sectional area (computed tomography). Differences in muscle strength, muscle area, and muscle quality ratio with age were evaluated, and the association between the muscle quality ratio and measures reflecting domains of cognitive function, motor control, peripheral nerve function, adiposity, glucose homeostasis, and inflammation were assessed through multivariate regression analyses. Results A linear relationship between age and muscle quality ratio was observed, suggesting a gradual decline in muscle quality over the adult life course. Associations were observed between muscle quality ratio and measures of adiposity, as well as peroneal nerve motor conduction velocity, finger tapping speed, and memory performance (P

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalJournal of the American Geriatrics Society
Volume62
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

Fingerprint

Baltimore
Longitudinal Studies
Muscles
Adiposity
Peroneal Nerve
Neural Conduction
Muscle Strength
Body Size
Proxy
Thigh
Peripheral Nerves
Cognition
Fingers
Knee
Homeostasis
Multivariate Analysis
Cross-Sectional Studies

Keywords

  • muscle area
  • muscle quality
  • muscle strength

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Moore, A. Z., Caturegli, G., Metter, E. J., Makrogiannis, S., Resnick, S. M., Harris, T. B., & Ferrucci, L. (2014). Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging. Journal of the American Geriatrics Society, 62(2), 230-236. https://doi.org/10.1111/jgs.12653

Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging. / Moore, Ann Zenobia; Caturegli, Giorgio; Metter, E. Jeffrey; Makrogiannis, Sokratis; Resnick, Susan M.; Harris, Tamara B.; Ferrucci, Luigi.

In: Journal of the American Geriatrics Society, Vol. 62, No. 2, 02.2014, p. 230-236.

Research output: Contribution to journalArticle

Moore, AZ, Caturegli, G, Metter, EJ, Makrogiannis, S, Resnick, SM, Harris, TB & Ferrucci, L 2014, 'Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging', Journal of the American Geriatrics Society, vol. 62, no. 2, pp. 230-236. https://doi.org/10.1111/jgs.12653
Moore, Ann Zenobia ; Caturegli, Giorgio ; Metter, E. Jeffrey ; Makrogiannis, Sokratis ; Resnick, Susan M. ; Harris, Tamara B. ; Ferrucci, Luigi. / Difference in muscle quality over the adult life span and biological correlates in the baltimore longitudinal study of aging. In: Journal of the American Geriatrics Society. 2014 ; Vol. 62, No. 2. pp. 230-236.
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