Dietary Zinc and Incident Calcium Kidney Stones in Adolescence

Gregory E. Tasian, Michelle E. Ross, Lihai Song, Robert W. Grundmeier, James Massey, Michelle R. Denburg, Lawrence Copelovitch, Steven Warner, Thomas Chi, David W. Killilea, Marshall L. Stoller, Susan L. Furth

Research output: Contribution to journalArticle

Abstract

Purpose We determined the association between dietary zinc intake and incident calcium kidney stones in adolescents. We also examined the relationship between dietary zinc intake and urinary zinc excretion between cases and controls. Materials and Methods We conducted a nested case-control study within a large pediatric health care system. Three 24-hour dietary recalls and spot urine chemistry analyses were obtained for 30 participants 12 to 18 years old with a first idiopathic calcium based kidney stone and 30 healthy controls matched for age, sex, race and month of enrollment. Conditional logistic regression models were used to estimate the association between daily zinc intake and incident calcium kidney stones, adjusting for dietary phytate, protein, calcium, sodium and oxalate. Multivariable linear regression was used to estimate the association between dietary and urine zinc, adjusting for urine creatinine and dietary phytate and calcium. Results Cases had lower daily zinc intake (8.1 mg) than controls (10 mg, p = 0.029). Daily zinc intake of boys and girls with calcium stones was 2 mg and 1.2 mg less, respectively, than the daily intake recommended by the Institute of Medicine. Odds of incident stones were reduced by 13% for every 1 mg increase in daily zinc intake (OR 0.87, 95% CI 0.75–0.99). There was an estimated 4.5 μg/dl increase in urine zinc for every 1 mg increase in dietary zinc (p = 0.009), with weak evidence of a smaller increase in urine zinc in cases than in controls (interaction p = 0.08). Conclusions Decreased dietary zinc intake was independently associated with incident calcium nephrolithiasis in this population of adolescents.

Original languageEnglish (US)
Pages (from-to)1342-1348
Number of pages7
JournalJournal of Urology
Volume197
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

Kidney Calculi
Zinc
Calcium
Urine
Phytic Acid
Logistic Models
Oxalic Acid
Dietary Calcium
Recommended Dietary Allowances
Nephrolithiasis
Calcium Oxalate
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Dietary Proteins
Case-Control Studies
Linear Models
Creatinine

Keywords

  • kidney calculi
  • nutritional status
  • pediatrics
  • zinc

ASJC Scopus subject areas

  • Urology

Cite this

Tasian, G. E., Ross, M. E., Song, L., Grundmeier, R. W., Massey, J., Denburg, M. R., ... Furth, S. L. (2017). Dietary Zinc and Incident Calcium Kidney Stones in Adolescence. Journal of Urology, 197(5), 1342-1348. https://doi.org/10.1016/j.juro.2016.11.096

Dietary Zinc and Incident Calcium Kidney Stones in Adolescence. / Tasian, Gregory E.; Ross, Michelle E.; Song, Lihai; Grundmeier, Robert W.; Massey, James; Denburg, Michelle R.; Copelovitch, Lawrence; Warner, Steven; Chi, Thomas; Killilea, David W.; Stoller, Marshall L.; Furth, Susan L.

In: Journal of Urology, Vol. 197, No. 5, 01.05.2017, p. 1342-1348.

Research output: Contribution to journalArticle

Tasian, GE, Ross, ME, Song, L, Grundmeier, RW, Massey, J, Denburg, MR, Copelovitch, L, Warner, S, Chi, T, Killilea, DW, Stoller, ML & Furth, SL 2017, 'Dietary Zinc and Incident Calcium Kidney Stones in Adolescence', Journal of Urology, vol. 197, no. 5, pp. 1342-1348. https://doi.org/10.1016/j.juro.2016.11.096
Tasian GE, Ross ME, Song L, Grundmeier RW, Massey J, Denburg MR et al. Dietary Zinc and Incident Calcium Kidney Stones in Adolescence. Journal of Urology. 2017 May 1;197(5):1342-1348. https://doi.org/10.1016/j.juro.2016.11.096
Tasian, Gregory E. ; Ross, Michelle E. ; Song, Lihai ; Grundmeier, Robert W. ; Massey, James ; Denburg, Michelle R. ; Copelovitch, Lawrence ; Warner, Steven ; Chi, Thomas ; Killilea, David W. ; Stoller, Marshall L. ; Furth, Susan L. / Dietary Zinc and Incident Calcium Kidney Stones in Adolescence. In: Journal of Urology. 2017 ; Vol. 197, No. 5. pp. 1342-1348.
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abstract = "Purpose We determined the association between dietary zinc intake and incident calcium kidney stones in adolescents. We also examined the relationship between dietary zinc intake and urinary zinc excretion between cases and controls. Materials and Methods We conducted a nested case-control study within a large pediatric health care system. Three 24-hour dietary recalls and spot urine chemistry analyses were obtained for 30 participants 12 to 18 years old with a first idiopathic calcium based kidney stone and 30 healthy controls matched for age, sex, race and month of enrollment. Conditional logistic regression models were used to estimate the association between daily zinc intake and incident calcium kidney stones, adjusting for dietary phytate, protein, calcium, sodium and oxalate. Multivariable linear regression was used to estimate the association between dietary and urine zinc, adjusting for urine creatinine and dietary phytate and calcium. Results Cases had lower daily zinc intake (8.1 mg) than controls (10 mg, p = 0.029). Daily zinc intake of boys and girls with calcium stones was 2 mg and 1.2 mg less, respectively, than the daily intake recommended by the Institute of Medicine. Odds of incident stones were reduced by 13{\%} for every 1 mg increase in daily zinc intake (OR 0.87, 95{\%} CI 0.75–0.99). There was an estimated 4.5 μg/dl increase in urine zinc for every 1 mg increase in dietary zinc (p = 0.009), with weak evidence of a smaller increase in urine zinc in cases than in controls (interaction p = 0.08). Conclusions Decreased dietary zinc intake was independently associated with incident calcium nephrolithiasis in this population of adolescents.",
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AU - Ross, Michelle E.

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AU - Massey, James

AU - Denburg, Michelle R.

AU - Copelovitch, Lawrence

AU - Warner, Steven

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N2 - Purpose We determined the association between dietary zinc intake and incident calcium kidney stones in adolescents. We also examined the relationship between dietary zinc intake and urinary zinc excretion between cases and controls. Materials and Methods We conducted a nested case-control study within a large pediatric health care system. Three 24-hour dietary recalls and spot urine chemistry analyses were obtained for 30 participants 12 to 18 years old with a first idiopathic calcium based kidney stone and 30 healthy controls matched for age, sex, race and month of enrollment. Conditional logistic regression models were used to estimate the association between daily zinc intake and incident calcium kidney stones, adjusting for dietary phytate, protein, calcium, sodium and oxalate. Multivariable linear regression was used to estimate the association between dietary and urine zinc, adjusting for urine creatinine and dietary phytate and calcium. Results Cases had lower daily zinc intake (8.1 mg) than controls (10 mg, p = 0.029). Daily zinc intake of boys and girls with calcium stones was 2 mg and 1.2 mg less, respectively, than the daily intake recommended by the Institute of Medicine. Odds of incident stones were reduced by 13% for every 1 mg increase in daily zinc intake (OR 0.87, 95% CI 0.75–0.99). There was an estimated 4.5 μg/dl increase in urine zinc for every 1 mg increase in dietary zinc (p = 0.009), with weak evidence of a smaller increase in urine zinc in cases than in controls (interaction p = 0.08). Conclusions Decreased dietary zinc intake was independently associated with incident calcium nephrolithiasis in this population of adolescents.

AB - Purpose We determined the association between dietary zinc intake and incident calcium kidney stones in adolescents. We also examined the relationship between dietary zinc intake and urinary zinc excretion between cases and controls. Materials and Methods We conducted a nested case-control study within a large pediatric health care system. Three 24-hour dietary recalls and spot urine chemistry analyses were obtained for 30 participants 12 to 18 years old with a first idiopathic calcium based kidney stone and 30 healthy controls matched for age, sex, race and month of enrollment. Conditional logistic regression models were used to estimate the association between daily zinc intake and incident calcium kidney stones, adjusting for dietary phytate, protein, calcium, sodium and oxalate. Multivariable linear regression was used to estimate the association between dietary and urine zinc, adjusting for urine creatinine and dietary phytate and calcium. Results Cases had lower daily zinc intake (8.1 mg) than controls (10 mg, p = 0.029). Daily zinc intake of boys and girls with calcium stones was 2 mg and 1.2 mg less, respectively, than the daily intake recommended by the Institute of Medicine. Odds of incident stones were reduced by 13% for every 1 mg increase in daily zinc intake (OR 0.87, 95% CI 0.75–0.99). There was an estimated 4.5 μg/dl increase in urine zinc for every 1 mg increase in dietary zinc (p = 0.009), with weak evidence of a smaller increase in urine zinc in cases than in controls (interaction p = 0.08). Conclusions Decreased dietary zinc intake was independently associated with incident calcium nephrolithiasis in this population of adolescents.

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