Abstract
The present study explored the association between dietary vitamin D and non-Hodgkin's lymphoma (NHL) risk. The multiethnic cohort (MEC) includes more than 215000 Caucasians, African Americans, Native Hawaiians, Japanese Americans and Latinos, aged 45-75. After 10 years of follow-up, 939 incident NHL cases were identified. Risk was estimated using proportional hazards' models adjusted for possible confounders. Vitamin D intake was not associated with NHL risk in the entire cohort (Ptrend=072 for men and Ptrend=083 for women), but significantly lowered disease risk in African American women (hazard ratio (HR)=050, 95% CI: 028, 090, Ptrend=003) and was borderline protective in African American men (HR=068; 95% CI: 039, 119; P trend=031) when the highest to the lowest tertile was compared. In NHL subtype analyses, a 19, 36 and 32% lowered risk, although not significant, was observed for diffuse large B-cell lymphoma, follicular lymphoma and small lymphocytic lymphoma/chronic lymphocytic leukemia in women, respectively. High dietary intake of vitamin D did not show a protective effect against NHL within the MEC except among African Americans, possibly because vitamin D production due to sun exposure is limited in this population.
Original language | English (US) |
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Pages (from-to) | 581-584 |
Number of pages | 4 |
Journal | British Journal of Nutrition |
Volume | 103 |
Issue number | 4 |
DOIs | |
State | Published - Feb 2010 |
Externally published | Yes |
Keywords
- Dietary vitamin D
- Ethnicity
- Non-Hodgkin lymphoma
- Prospective studies
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics