Dietary vitamin D and risk of non-Hodgkin lymphoma: The multiethnic cohort

Eva Oakkar, Gertraud Maskarinec, Unhee Lim, Laurence N. Kolonel

Research output: Contribution to journalArticle

Abstract

The present study explored the association between dietary vitamin D and non-Hodgkin's lymphoma (NHL) risk. The multiethnic cohort (MEC) includes more than 215000 Caucasians, African Americans, Native Hawaiians, Japanese Americans and Latinos, aged 45-75. After 10 years of follow-up, 939 incident NHL cases were identified. Risk was estimated using proportional hazards' models adjusted for possible confounders. Vitamin D intake was not associated with NHL risk in the entire cohort (Ptrend=072 for men and Ptrend=083 for women), but significantly lowered disease risk in African American women (hazard ratio (HR)=050, 95% CI: 028, 090, Ptrend=003) and was borderline protective in African American men (HR=068; 95% CI: 039, 119; P trend=031) when the highest to the lowest tertile was compared. In NHL subtype analyses, a 19, 36 and 32% lowered risk, although not significant, was observed for diffuse large B-cell lymphoma, follicular lymphoma and small lymphocytic lymphoma/chronic lymphocytic leukemia in women, respectively. High dietary intake of vitamin D did not show a protective effect against NHL within the MEC except among African Americans, possibly because vitamin D production due to sun exposure is limited in this population.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalBritish Journal of Nutrition
Volume103
Issue number4
DOIs
StatePublished - Feb 2010
Externally publishedYes

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Vitamin D
Non-Hodgkin's Lymphoma
African Americans
B-Cell Chronic Lymphocytic Leukemia
Oceanic Ancestry Group
Follicular Lymphoma
Asian Americans
Lymphoma, Large B-Cell, Diffuse
Solar System
Hispanic Americans
Proportional Hazards Models
Population

Keywords

  • Dietary vitamin D
  • Ethnicity
  • Non-Hodgkin lymphoma
  • Prospective studies

ASJC Scopus subject areas

  • Medicine(all)
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Dietary vitamin D and risk of non-Hodgkin lymphoma : The multiethnic cohort. / Oakkar, Eva; Maskarinec, Gertraud; Lim, Unhee; Kolonel, Laurence N.

In: British Journal of Nutrition, Vol. 103, No. 4, 02.2010, p. 581-584.

Research output: Contribution to journalArticle

Oakkar, Eva ; Maskarinec, Gertraud ; Lim, Unhee ; Kolonel, Laurence N. / Dietary vitamin D and risk of non-Hodgkin lymphoma : The multiethnic cohort. In: British Journal of Nutrition. 2010 ; Vol. 103, No. 4. pp. 581-584.
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