Leczenie padaczki dietą: Renesans starej terapii

Translated title of the contribution: Dietary treatment of epilepsy: Rebirth of an ancient treatment

Sergiusz Jóźwiak, Eric H. Kossoff, Katarzyna Kotulska-Jóźwiak

Research output: Contribution to journalReview article

Abstract

Since its introduction in 1921, the ketogenic diet has been incontinuous use for children with difficult-to-control epilepsy.After decades of relative disuse, it is now both extremelypopular and well studied, with approximately two-thirds ofchildren demonstrating significant seizure reduction after 6 months. It is being used for less intractable seizures in childrenas well as recently adults. Modifications that helpimprove tolerability include the medium chain triglyceridediet, modified Atkins diet, and low glycemic index treatment.Major side effects include acidosis, increased cholesterol, kidneystones, gastroesophageal reflux, and growth disturbance.However, these side effects are usually treatable and nowadaysoften even preventable. Future non-epilepsy indicationssuch as Alzheimer disease, amyotrophic lateral sclerosis,autism, and brain tumors are under active investigation. Thisdietary treatment for epilepsy has undergone a rebirth. Itswidespread use in Poland and Europe is a welcome additionaltreatment for those with drug-resistant epilepsy.

Translated title of the contributionDietary treatment of epilepsy: Rebirth of an ancient treatment
Original languagePolish
Pages (from-to)370-378
Number of pages9
JournalNeurologia i Neurochirurgia Polska
Volume45
Issue number4
DOIs
StatePublished - Jan 1 2011

Keywords

  • Epilepsy
  • Ketogenic diet
  • Treatment

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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