Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury

W. Duan, J. Lee, Z. Guo, M. P. Mattson

Research output: Contribution to journalArticlepeer-review

Abstract

Dietary restriction (DR) increases the lifespan of rodents and increases their resistance to several different age-related diseases including cancer and diabetes. Beneficial effects of DR on brain plasticity and neuronal vulnerability to injury have recently been reported, but the underlying mechanisms are unknown. We report that levels of brain-derived neurotrophic factor (BDNF) are significantly increased in the hippocampus, cerebral cortex, and striatum of rats maintained on a DR regimen compared to animals fed ad libitum (AL). Seizure-induced damage to hippocampal neurons was significantly reduced in rats maintained on DR, and this beneficial effect was attenuated by intraventricular administration of a BDNF-blocking antibody. These findings provide the first evidence that diet can effect expression of a neurotrophic factor, demonstrate that BDNF signaling plays a central role in the neuroprotective effect of DR, and proffer DR as an approach for reducing neuronal damage in neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalJournal of Molecular Neuroscience
Volume16
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Apoptosis
  • BDNF
  • Caloric restriction
  • Cerebral cortex
  • Epileptic seizures
  • Glutamate

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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