Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents

June Zhou, Michael J. Keenan, Sun Ok Fernandez-Kim, Paul J. Pistell, Donald K. Ingram, Bing Li, Anne M. Raggio, Li Shen, Hanjie Zhang, Kathleen L. Mccutcheon, Richard T. Tulley, Marc R. Blackman, Jeffrey N. Keller, Roy J. Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Resistant starch (RS) is a dietary fiber that exerts multiple beneficial effects. The current study explored the effects of dietary RS on selected brain and behavioral functions in adult and aged rodents. Because glucokinase (GK) expression in hypothalamic arcuate nucleus and area postrema of the brainstem is important for brain glucose sensing, GK mRNA was measured by brain nuclei microdissection and PCR. Adult RS-fed rats had a higher GK mRNA than controls in both brain nuclei, an indicator of improved brain glucose sensing. Next, we tested whether dietary RS improve selected behaviors in aged mice. RS-fed aged mice exhibited (i) an increased eating responses to fasting, a behavioral indicator of improvement in aged brain glucose sensing; (ii) a longer latency to fall from an accelerating rotarod, a behavioral indicator of improved motor coordination; and (iii) a higher serum active glucagon-like peptide-1 (GLP-1). Then, GLP-1 receptor null (GLP-1RKO) mice were used to test the role of GLP-1 in brain glucose sensing, and they exhibited impaired eating responses to fasting. We conclude that in rodents (i) dietary RS improves two important indicators of brain function: glucose sensing and motor coordination, and (ii) GLP-1 is important in the optimal feeding response to a fast.

Original languageEnglish (US)
Pages (from-to)2071-2074
Number of pages4
JournalMolecular Nutrition and Food Research
Volume57
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Aging
  • Brain function
  • GK
  • GLP-1
  • Glucose sensing

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Fingerprint

Dive into the research topics of 'Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents'. Together they form a unique fingerprint.

Cite this