TY - JOUR
T1 - Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids
T2 - Signaling pathways as target
AU - Islam, Md Soriful
AU - Segars, James H.
AU - Castellucci, Mario
AU - Ciarmela, Pasquapina
N1 - Funding Information:
This work was supported by a grant from the “Fondazione Cassa di Risparmio di Fabriano e Cupramontana” (to MC and PC).
Publisher Copyright:
© 2016 Institute of Pharmacology, Polish Academy of Sciences
PY - 2017/2/1
Y1 - 2017/2/1
N2 - A growing interest has emerged on dietary phytochemicals to control diverse pathological conditions. Unfortunately, dietary phytochemical research in uterine fibroids is still under construction. Uterine fibroids/leiomyomas are benign tumors developing from the myometrium of the uterus in premenopausal women. They may occur in more than 70% of women, and approximately 25% of women show clinically significant symptoms. These include heavy and prolonged menstrual bleeding, pelvic pressure (urinary frequency, incontinence, and difficulty with urination), pelvic pain, pelvic mass, infertility, and reproductive dysfunction. Due to lack of medical treatments surgery has been definitive choice for fibroid management. Moreover, surgery negatively affects women's quality of life, and its associated cost appears to be expensive. The molecular mechanism of fibroids development and growth is not fully elucidated. However, accumulated evidence shows that several signaling pathways, including Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin are involved in the leiomyoma pathogenesis, indicating that they could serve as targets for prevention and/or treatment of this tumor. Therefore, in this review, we discuss the involvement of signaling pathways in leiomyoma development and growth, and introduce some potential dietary phytochemicals that could modulate those signaling pathways.
AB - A growing interest has emerged on dietary phytochemicals to control diverse pathological conditions. Unfortunately, dietary phytochemical research in uterine fibroids is still under construction. Uterine fibroids/leiomyomas are benign tumors developing from the myometrium of the uterus in premenopausal women. They may occur in more than 70% of women, and approximately 25% of women show clinically significant symptoms. These include heavy and prolonged menstrual bleeding, pelvic pressure (urinary frequency, incontinence, and difficulty with urination), pelvic pain, pelvic mass, infertility, and reproductive dysfunction. Due to lack of medical treatments surgery has been definitive choice for fibroid management. Moreover, surgery negatively affects women's quality of life, and its associated cost appears to be expensive. The molecular mechanism of fibroids development and growth is not fully elucidated. However, accumulated evidence shows that several signaling pathways, including Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin are involved in the leiomyoma pathogenesis, indicating that they could serve as targets for prevention and/or treatment of this tumor. Therefore, in this review, we discuss the involvement of signaling pathways in leiomyoma development and growth, and introduce some potential dietary phytochemicals that could modulate those signaling pathways.
KW - Dietary phytochemicals
KW - Growth factors
KW - Medical treatment
KW - Signaling pathways
KW - Uterine fibroids
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U2 - 10.1016/j.pharep.2016.10.013
DO - 10.1016/j.pharep.2016.10.013
M3 - Review article
C2 - 27898339
AN - SCOPUS:84997719830
SN - 1734-1140
VL - 69
SP - 57
EP - 70
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 1
ER -