Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target

Md Soriful Islam, James Segars, Mario Castellucci, Pasquapina Ciarmela

Research output: Contribution to journalReview article

Abstract

A growing interest has emerged on dietary phytochemicals to control diverse pathological conditions. Unfortunately, dietary phytochemical research in uterine fibroids is still under construction. Uterine fibroids/leiomyomas are benign tumors developing from the myometrium of the uterus in premenopausal women. They may occur in more than 70% of women, and approximately 25% of women show clinically significant symptoms. These include heavy and prolonged menstrual bleeding, pelvic pressure (urinary frequency, incontinence, and difficulty with urination), pelvic pain, pelvic mass, infertility, and reproductive dysfunction. Due to lack of medical treatments surgery has been definitive choice for fibroid management. Moreover, surgery negatively affects women's quality of life, and its associated cost appears to be expensive. The molecular mechanism of fibroids development and growth is not fully elucidated. However, accumulated evidence shows that several signaling pathways, including Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin are involved in the leiomyoma pathogenesis, indicating that they could serve as targets for prevention and/or treatment of this tumor. Therefore, in this review, we discuss the involvement of signaling pathways in leiomyoma development and growth, and introduce some potential dietary phytochemicals that could modulate those signaling pathways.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalPharmacological Reports
Volume69
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Dietary phytochemicals
  • Growth factors
  • Medical treatment
  • Signaling pathways
  • Uterine fibroids

ASJC Scopus subject areas

  • Pharmacology

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