TY - JOUR
T1 - Dietary patterns derived from principal component analysis (PCA) and risk of colorectal cancer
T2 - a systematic review and meta-analysis
AU - Garcia-Larsen, Vanessa
AU - Morton, Victoria
AU - Norat, Teresa
AU - Moreira, André
AU - Potts, James F.
AU - Reeves, Tim
AU - Bakolis, Ioannis
N1 - Funding Information:
Funding Victoria Morton was a Master of Public Health (MPH) at Imperial College London and did this work as part of her Dissertation (Distinction). She was funded through a BUPA Foundation Grant No TBP-PPW10-064 awarded to Dr Vanessa Garcia-Larsen. Dr Ioannis Bakolis is funded by the National Institute for Health Research (NIHR) Biomedical Research at South London and Maudsley NHS Foundation Trust and King”s College London, and by National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King”s College Hospital NHS Foundation Trust and King” College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health.
Publisher Copyright:
© 2018, Macmillan Publishers Limited, part of Springer Nature.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background and aim: Colorectal cancer (CRC) is highly prevalent worldwide, with dietary habits being a major risk factor. We systematically reviewed and meta-analysed the observational evidence on the association between CRC and dietary patterns (DP) derived from principal component analysis. Design: PRISMA guidelines were followed. Web of Science, Medline/PubMed, EMBASE, and The Cochrane Library were searched to identify all eligible papers published up to the 31st July 2017. Any pre-defined cancer of the colon was included, namely colon-rectal cancer (CRC), colon cancer (CC), rectal cancer (RC), or proximal and distal CC, if available. Western (WDP) and prudent (PDP) dietary patterns were compared as a proxy to estimate “unhealthy” (Rich in meat and processed foods) and “healthy” diets (containing fruits or vegetables), respectively. Meta-analyses were carried out using random effects model to calculate overall risk estimates. Relative risks (RR) and 95% confidence intervals were estimated comparing the highest versus the lowest categories of dietary patterns for any of the forms of colon cancer studied. Results: 28 studies were meta-analysed. A WDP was associated with increased risk of CRC (RR 1.25; 95% CI 1.11, 1.40), and of CC (RR 1.30; 95% CI 1.11, 1.52). A PDP was negatively associated with CRC (RR 0.81; 95% CI 0.73, 0.91). Sensitivity analyses showed that individuals from North-and South-American countries had a significantly higher risk of CRC than those from other continents. Conclusion: A PDP might reduce the risk of CRC. Conversely, a WDP is associated with a higher risk of disease.
AB - Background and aim: Colorectal cancer (CRC) is highly prevalent worldwide, with dietary habits being a major risk factor. We systematically reviewed and meta-analysed the observational evidence on the association between CRC and dietary patterns (DP) derived from principal component analysis. Design: PRISMA guidelines were followed. Web of Science, Medline/PubMed, EMBASE, and The Cochrane Library were searched to identify all eligible papers published up to the 31st July 2017. Any pre-defined cancer of the colon was included, namely colon-rectal cancer (CRC), colon cancer (CC), rectal cancer (RC), or proximal and distal CC, if available. Western (WDP) and prudent (PDP) dietary patterns were compared as a proxy to estimate “unhealthy” (Rich in meat and processed foods) and “healthy” diets (containing fruits or vegetables), respectively. Meta-analyses were carried out using random effects model to calculate overall risk estimates. Relative risks (RR) and 95% confidence intervals were estimated comparing the highest versus the lowest categories of dietary patterns for any of the forms of colon cancer studied. Results: 28 studies were meta-analysed. A WDP was associated with increased risk of CRC (RR 1.25; 95% CI 1.11, 1.40), and of CC (RR 1.30; 95% CI 1.11, 1.52). A PDP was negatively associated with CRC (RR 0.81; 95% CI 0.73, 0.91). Sensitivity analyses showed that individuals from North-and South-American countries had a significantly higher risk of CRC than those from other continents. Conclusion: A PDP might reduce the risk of CRC. Conversely, a WDP is associated with a higher risk of disease.
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U2 - 10.1038/s41430-018-0234-7
DO - 10.1038/s41430-018-0234-7
M3 - Review article
C2 - 30050075
AN - SCOPUS:85050695850
VL - 73
SP - 366
EP - 386
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 3
ER -