Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease

Eyal Shahar, Aaron R. Folsom, Sandra L. Melnick, Melvyn S. Tockman, George W. Comstock, Valerio Gennaro, Millicent W. Higgins, Paul D. Sorlie, Wen Jene Ko, Moyses Szklo

Research output: Contribution to journalArticle

Abstract

Background. Fish contain n-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid, which are known to interfere with the body's inflammatory response and may be of benefit in chronic inflammatory conditions. Methods. We studied the relation between the dietary intake of n-3 fatty acids and chronic obstructive pulmonary disease (COPD) in 8960 current or former smokers participating in a population-based study of atherosclerosis. Intake of fatty acids was estimated with a dietary questionnaire. The presence of COPD was assessed by a questionnaire on respiratory symptoms and by spirometry. Three case definitions of COPD were used: symptoms of chronic bronchitis (667 subjects), physician-diagnosed emphysema reported by the subject (185 subjects), and spirometrically detected COPD (197 subjects). Results. After control for pack-years of smoking, age, sex, race, height, weight, energy intake, and educational level, the combined intake of eicosapentaenoic acid and docosahexaenoic acid was inversely related to the risk of COPD in a quantity-dependent fashion. The adjusted odds ratio for the highest quartile of intake as compared with the lowest quartile was 0.66 for chronic bronchitis (95 percent confidence interval, 0.52 to 0.85; P

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalNew England Journal of Medicine
Volume331
Issue number4
DOIs
StatePublished - Jul 28 1994

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Omega-3 Fatty Acids
Chronic Obstructive Pulmonary Disease
Smoking
Eicosapentaenoic Acid
Docosahexaenoic Acids
Chronic Bronchitis
Spirometry
Emphysema
Energy Intake
Atherosclerosis
Fishes
Fatty Acids
Odds Ratio
Confidence Intervals
Physicians
Weights and Measures
Population
Surveys and Questionnaires

ASJC Scopus subject areas

  • Medicine(all)

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Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. / Shahar, Eyal; Folsom, Aaron R.; Melnick, Sandra L.; Tockman, Melvyn S.; Comstock, George W.; Gennaro, Valerio; Higgins, Millicent W.; Sorlie, Paul D.; Ko, Wen Jene; Szklo, Moyses.

In: New England Journal of Medicine, Vol. 331, No. 4, 28.07.1994, p. 228-233.

Research output: Contribution to journalArticle

Shahar, E, Folsom, AR, Melnick, SL, Tockman, MS, Comstock, GW, Gennaro, V, Higgins, MW, Sorlie, PD, Ko, WJ & Szklo, M 1994, 'Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease', New England Journal of Medicine, vol. 331, no. 4, pp. 228-233. https://doi.org/10.1056/NEJM199407283310403
Shahar, Eyal ; Folsom, Aaron R. ; Melnick, Sandra L. ; Tockman, Melvyn S. ; Comstock, George W. ; Gennaro, Valerio ; Higgins, Millicent W. ; Sorlie, Paul D. ; Ko, Wen Jene ; Szklo, Moyses. / Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. In: New England Journal of Medicine. 1994 ; Vol. 331, No. 4. pp. 228-233.
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