Abstract
Other chapters in this book describe emerging findings concerning the roles of lipid rafts in physiological and pathological processes. The lipid components of rafts not only define their structure, but also influence the various signaling pathways associated with the rafts. It is well known that the lipid composition of cell membranes can be modified by various dietary lipids (Field et al., 1989). If raft lipids are subject to modification by diet, then presumably the signaling functions of the rafts are also affected by the diets. Although there is considerable evidence that dietary cholesterol and (to a lesser extent) sphingolipids can affect the functions of a variety of cell types, there have been few if any studies specifically addressing the effects of dietary lipids on raft-based signaling. However, given the multitude of signaling processes that involve lipid rafts (Fig. 1), it is important for investigators in a diverse array of fields to design studies aimed at establishing how dietary factors affect raft-based signaling in various cell types. The data obtained in such studies will have important implications for human health. In this chapter, I therefore consider a few ways in which dietary lipids and other dietary factors might affect lipid rafts in the context of cell types and signal transduction pathways involved in several prominent diseases.
| Original language | English (US) |
|---|---|
| Title of host publication | Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine |
| Publisher | Humana Press Inc. |
| Pages | 191-201 |
| Number of pages | 11 |
| ISBN (Print) | 9781592598038, 159259803X, 9781588293541 |
| DOIs | |
| State | Published - 2005 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Dietary modulation of lipid rafts : Implications for disease prevention and treatment. / Mattson, Mark P.
Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine. Humana Press Inc., 2005. p. 191-201.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Dietary modulation of lipid rafts
T2 - Implications for disease prevention and treatment
AU - Mattson, Mark P.
PY - 2005
Y1 - 2005
N2 - Other chapters in this book describe emerging findings concerning the roles of lipid rafts in physiological and pathological processes. The lipid components of rafts not only define their structure, but also influence the various signaling pathways associated with the rafts. It is well known that the lipid composition of cell membranes can be modified by various dietary lipids (Field et al., 1989). If raft lipids are subject to modification by diet, then presumably the signaling functions of the rafts are also affected by the diets. Although there is considerable evidence that dietary cholesterol and (to a lesser extent) sphingolipids can affect the functions of a variety of cell types, there have been few if any studies specifically addressing the effects of dietary lipids on raft-based signaling. However, given the multitude of signaling processes that involve lipid rafts (Fig. 1), it is important for investigators in a diverse array of fields to design studies aimed at establishing how dietary factors affect raft-based signaling in various cell types. The data obtained in such studies will have important implications for human health. In this chapter, I therefore consider a few ways in which dietary lipids and other dietary factors might affect lipid rafts in the context of cell types and signal transduction pathways involved in several prominent diseases.
AB - Other chapters in this book describe emerging findings concerning the roles of lipid rafts in physiological and pathological processes. The lipid components of rafts not only define their structure, but also influence the various signaling pathways associated with the rafts. It is well known that the lipid composition of cell membranes can be modified by various dietary lipids (Field et al., 1989). If raft lipids are subject to modification by diet, then presumably the signaling functions of the rafts are also affected by the diets. Although there is considerable evidence that dietary cholesterol and (to a lesser extent) sphingolipids can affect the functions of a variety of cell types, there have been few if any studies specifically addressing the effects of dietary lipids on raft-based signaling. However, given the multitude of signaling processes that involve lipid rafts (Fig. 1), it is important for investigators in a diverse array of fields to design studies aimed at establishing how dietary factors affect raft-based signaling in various cell types. The data obtained in such studies will have important implications for human health. In this chapter, I therefore consider a few ways in which dietary lipids and other dietary factors might affect lipid rafts in the context of cell types and signal transduction pathways involved in several prominent diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=79957791370&partnerID=8YFLogxK
U2 - 10.1385/1-59259-803-X:191
DO - 10.1385/1-59259-803-X:191
M3 - Chapter
AN - SCOPUS:79957791370
SN - 9781592598038
SN - 159259803X
SN - 9781588293541
SP - 191
EP - 201
BT - Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine
PB - Humana Press Inc.
ER -