Dietary intake of flavonoids and ventilatory function in european adults

A GA2LEN study

Vanessa Garcia-Larsen    , Narjis Thawer, David Charles, Aedin Cassidy, Thibaut Van Zele, Trine Thilsing, Matti Ahlström, Tari Haahtela, Thomas Keil, Paolo M. Matricardi, Grzegorz Brożek, Marek L. Kowalski, Joanna Makowska, Ewa Niżankowska-Mogilnicka, Barbara Rymarczyk, Carlos Loureiro, Ana Todo Bom, Claus Bachert, Bertil Forsberg, Christer Janson & 3 others Kjell Torén, James F. Potts, Peter Gj Burney

Research output: Contribution to journalArticle

Abstract

Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58, 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47, 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33, 0.10, 0.57 and a β-coeff 0.44, 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.

Original languageEnglish (US)
Article number95
JournalNutrients
Volume10
Issue number1
DOIs
StatePublished - Jan 15 2018

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Vital Capacity
Flavonoids
food intake
flavonoids
anthocyanidins
Anthocyanins
confidence interval
lung function
Confidence Intervals
odds ratio
Odds Ratio
bronchodilators
Lung
Bronchodilator Agents
Spirometry
food frequency questionnaires
anti-inflammatory activity
epidemiological studies
signs and symptoms (animals and humans)
protective effect

Keywords

  • Flavonoids
  • GA2LEN
  • Lung function
  • Pro-anthocyanidins

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Garcia-Larsen    , V., Thawer, N., Charles, D., Cassidy, A., Van Zele, T., Thilsing, T., ... Burney, P. G. (2018). Dietary intake of flavonoids and ventilatory function in european adults: A GA2LEN study. Nutrients, 10(1), [95]. https://doi.org/10.3390/nu10010095

Dietary intake of flavonoids and ventilatory function in european adults : A GA2LEN study. / Garcia-Larsen    , Vanessa; Thawer, Narjis; Charles, David; Cassidy, Aedin; Van Zele, Thibaut; Thilsing, Trine; Ahlström, Matti; Haahtela, Tari; Keil, Thomas; Matricardi, Paolo M.; Brożek, Grzegorz; Kowalski, Marek L.; Makowska, Joanna; Niżankowska-Mogilnicka, Ewa; Rymarczyk, Barbara; Loureiro, Carlos; Bom, Ana Todo; Bachert, Claus; Forsberg, Bertil; Janson, Christer; Torén, Kjell; Potts, James F.; Burney, Peter Gj.

In: Nutrients, Vol. 10, No. 1, 95, 15.01.2018.

Research output: Contribution to journalArticle

Garcia-Larsen    , V, Thawer, N, Charles, D, Cassidy, A, Van Zele, T, Thilsing, T, Ahlström, M, Haahtela, T, Keil, T, Matricardi, PM, Brożek, G, Kowalski, ML, Makowska, J, Niżankowska-Mogilnicka, E, Rymarczyk, B, Loureiro, C, Bom, AT, Bachert, C, Forsberg, B, Janson, C, Torén, K, Potts, JF & Burney, PG 2018, 'Dietary intake of flavonoids and ventilatory function in european adults: A GA2LEN study', Nutrients, vol. 10, no. 1, 95. https://doi.org/10.3390/nu10010095
Garcia-Larsen    , Vanessa ; Thawer, Narjis ; Charles, David ; Cassidy, Aedin ; Van Zele, Thibaut ; Thilsing, Trine ; Ahlström, Matti ; Haahtela, Tari ; Keil, Thomas ; Matricardi, Paolo M. ; Brożek, Grzegorz ; Kowalski, Marek L. ; Makowska, Joanna ; Niżankowska-Mogilnicka, Ewa ; Rymarczyk, Barbara ; Loureiro, Carlos ; Bom, Ana Todo ; Bachert, Claus ; Forsberg, Bertil ; Janson, Christer ; Torén, Kjell ; Potts, James F. ; Burney, Peter Gj. / Dietary intake of flavonoids and ventilatory function in european adults : A GA2LEN study. In: Nutrients. 2018 ; Vol. 10, No. 1.
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abstract = "Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58, 95{\%} Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47, 95{\%} CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33, 0.10, 0.57 and a β-coeff 0.44, 95{\%} CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.",
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T1 - Dietary intake of flavonoids and ventilatory function in european adults

T2 - A GA2LEN study

AU - Garcia-Larsen    , Vanessa

AU - Thawer, Narjis

AU - Charles, David

AU - Cassidy, Aedin

AU - Van Zele, Thibaut

AU - Thilsing, Trine

AU - Ahlström, Matti

AU - Haahtela, Tari

AU - Keil, Thomas

AU - Matricardi, Paolo M.

AU - Brożek, Grzegorz

AU - Kowalski, Marek L.

AU - Makowska, Joanna

AU - Niżankowska-Mogilnicka, Ewa

AU - Rymarczyk, Barbara

AU - Loureiro, Carlos

AU - Bom, Ana Todo

AU - Bachert, Claus

AU - Forsberg, Bertil

AU - Janson, Christer

AU - Torén, Kjell

AU - Potts, James F.

AU - Burney, Peter Gj

PY - 2018/1/15

Y1 - 2018/1/15

N2 - Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58, 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47, 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33, 0.10, 0.57 and a β-coeff 0.44, 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.

AB - Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58, 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47, 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33, 0.10, 0.57 and a β-coeff 0.44, 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.

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KW - GA2LEN

KW - Lung function

KW - Pro-anthocyanidins

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