@article{baf0f232a8214acf834b30b1055bd5d8,
title = "Dietary intake from complementary feeding is associated with intestinal barrier function and environmental enteropathy in Brazilian children from the MAL-ED cohort study",
abstract = "A child's diet contains nutrients and other substances that influence intestinal health. The present study aimed to evaluate the relations between complementary feeding, intestinal barrier function and environmental enteropathy (EE) in infants. Data from 233 children were obtained from the Brazilian site of the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project cohort study. Habitual dietary intake from complementary feeding was estimated using seven 24-h dietary recalls, from 9 to 15 months of age. Intestinal barrier function was assessed using the lactulose-mannitol test (L-M), and EE was determined as a composite measure using faecal biomarkers concentrations - α-1-antitrypsin, myeloperoxidase (MPO) and neopterin (NEO) at 15 months of age. The nutrient adequacies explored the associations between dietary intake and the intestinal biomarkers. Children showed adequate nutrient intakes (with the exception of fibre), impaired intestinal barrier function and intestinal inflammation. There was a negative correlation between energy adequacy and L-M (ρ = -0·19, P < 0·05) and between folate adequacy and NEO concentrations (ρ = -0·21, P < 0·01). In addition, there was a positive correlation between thiamine adequacy and MPO concentration (ρ = 0·22, P < 0·01) and between Ca adequacy and NEO concentration (ρ = 0·23; P < 0·01). Multiple linear regression models showed that energy intakes were inversely associated with intestinal barrier function (β = -0·19, P = 0·02), and fibre intake was inversely associated with the EE scores (β = -0·20, P = 0·04). Findings suggest that dietary intake from complementary feeding is associated with decreased intestinal barrier function and EE in children.",
keywords = "Biomarkers, Infants, Intestinal infections, Intestinal permeability, Nutrient intake",
author = "Costa, {P. N.} and Soares, {A. M.} and Filho, {J. Q.} and Junior, {F. S.} and R. Ambikapathi and {Rogawski McQuade}, {E. T.} and Guerrant, {R. L.} and Caulfield, {L. E.} and Lima, {A. A.M.} and Maciel, {B. L.L.}",
note = "Funding Information: The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) was a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the National Institutes of Health and the National Institutes of Health/Fogarty International Center (grant number OPP47075). The present study was financed in part by the Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior – Brasil – Finance Code 001. Funding Information: The authors gratefully acknowledge the families of the community of Parque Universit{\'a}rio, located in Fortaleza, enrolled in the MAL-ED cohort study for allowing us to visit and collect the samples analysed here, as well the staff of the MAL-ED Network Project for their valuable contributions. The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) was a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the National Institutes of Health and the National Institutes of Health/Fogarty International Center (grant number OPP47075). The present study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de N{\'i}vel Superior – Brasil – Finance Code 001. B. L. L. M., A. A. M. L., L. E. C. and R. L. G. conceived and designed the study; P. N. C., A. M. S., J. Q. F. and F. S. J. cleaned the data; P. N. C., R. A., E. T. R. M. and B. L. L. M. analysed and interpreted the data; P. N. C. and B. L. L. M. drafted and revised the manuscript. All authors reviewed and approved the final version of the manuscript. The authors declare that there are no conflicts of interest. Publisher Copyright: {\textcopyright} The Authors 2020.",
year = "2020",
doi = "10.1017/S0007114520000215",
language = "English (US)",
volume = "123",
pages = "1003--1012",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "9",
}