TY - JOUR
T1 - Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
AU - Dinkova-Kostova, Albena T.
AU - Fahey, Jed W.
AU - Benedict, Andrea L.
AU - Jenkins, Stephanie N.
AU - Ye, Lingxiang
AU - Wehage, Scott L.
AU - Talalay, Paul
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Feeding broccoli sprout extracts providing daily doses of 10 μmol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm-2 of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
AB - Feeding broccoli sprout extracts providing daily doses of 10 μmol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm-2 of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
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U2 - 10.1039/b9pp00130a
DO - 10.1039/b9pp00130a
M3 - Article
C2 - 20354656
AN - SCOPUS:77951114133
SN - 1474-905X
VL - 9
SP - 597
EP - 600
JO - Photochemical and Photobiological Sciences
JF - Photochemical and Photobiological Sciences
IS - 4
ER -