TY - JOUR
T1 - Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme
AU - Peters, Ulrike
AU - Sinha, Rashmi
AU - Chatterjee, Nilanjan
AU - Subar, Amy F.
AU - Ziegler, Regina G.
AU - Kulldorff, Martin
AU - Bresalier, Robert
AU - Weissfeld, Joel L.
AU - Flood, Andrew
AU - Schatzkin, Arthur
AU - Hayes, Richard B.
N1 - Funding Information:
The Prostate Lung Colorectal and Ovarian Cancer Screening Trial is fully funded by the National Cancer Institute, National Institutes of Health, Department of Health and Human Services of the US government.
PY - 2003/5/3
Y1 - 2003/5/3
N2 - Background: Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial. Methods: We used a 137-item food frequency questionnaire to assess the relation of fibre intake and frequency of colorectal adenoma. The study was done within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a randomised controlled trial designed to investigate methods for early detection of cancer. In our analysis, we compared fibre intake of 339 71 participants who were sigmoidoscopy-negative for polyps, with 3591 cases with at least one histologically verified adenoma in the distal large bowel (ie, descending colon, sigmoid colon, or rectum). Odds ratios were estimated by logistic regression analysis. Findings: High intakes of dietary fibre were associated with a lower risk of colorectal adenoma, after adjustment for potential dietary and non-dietary risk factors. Participants in the highest quintile of dietary fibre intake had a 27% (95% CI 14-38, ptrend=0.002) lower risk of adenoma than those in the lowest quintile. The inverse association was strongest for fibre from grains and cereals and from fruits. Risks were similar for advanced and non-advanced adenoma. Risk of rectal adenoma was not significantly associated with fibre intake. Interpretation: Dietary fibre, particularly from grains, cereals, and fruits, was associated with decreased risk of distal colon adenoma.
AB - Background: Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial. Methods: We used a 137-item food frequency questionnaire to assess the relation of fibre intake and frequency of colorectal adenoma. The study was done within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a randomised controlled trial designed to investigate methods for early detection of cancer. In our analysis, we compared fibre intake of 339 71 participants who were sigmoidoscopy-negative for polyps, with 3591 cases with at least one histologically verified adenoma in the distal large bowel (ie, descending colon, sigmoid colon, or rectum). Odds ratios were estimated by logistic regression analysis. Findings: High intakes of dietary fibre were associated with a lower risk of colorectal adenoma, after adjustment for potential dietary and non-dietary risk factors. Participants in the highest quintile of dietary fibre intake had a 27% (95% CI 14-38, ptrend=0.002) lower risk of adenoma than those in the lowest quintile. The inverse association was strongest for fibre from grains and cereals and from fruits. Risks were similar for advanced and non-advanced adenoma. Risk of rectal adenoma was not significantly associated with fibre intake. Interpretation: Dietary fibre, particularly from grains, cereals, and fruits, was associated with decreased risk of distal colon adenoma.
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U2 - 10.1016/S0140-6736(03)13173-X
DO - 10.1016/S0140-6736(03)13173-X
M3 - Article
C2 - 12737857
AN - SCOPUS:0037623300
SN - 0140-6736
VL - 361
SP - 1491
EP - 1495
JO - Lancet
JF - Lancet
IS - 9368
ER -