Dietary fiber, vegetables, and colon cancer: Critical review and meta-analyses of the epidemiologic evidence

Bruce Trock, Elaine Lanza, Peter Greenwald

Research output: Contribution to journalArticle

Abstract

Whether colon cancer risk can be modified by a diet rich in vegetables, grains, and fruit, and, if so, whether the protective factor is dietary fiber or other biologically active components correlated with a high-fiber diet are questions of active research interest. Because studies on diet are susceptible to bias from a number of sources, in this review we evaluated the adequacy of study methodology as well as study results to clarify how much protection, if any, is conferred by a high-fiber diet. The review consisted of an aggregate assessment of the strength of evidence from 37 observational epidemiologic studies as well as meta-analyses of data from 16 of the 23 case-control studies. Both types of analyses revealed that the majority of studies gave support for a protective effect associated with fiber-rich diets; an estimated combined odds ratio (OR) of 0.57 (95% confidence interval = 0.50, 0.64) was obtained when the highest and lowest quantiles of intake were compared. Risk estimates based on vegetable consumption (OR = 0.48) were only slightly more convincing than those based on an estimate of fiber intake (OR = 0.58), but the data do not permit discrimination between effects due to fiber and nonfiber effects due to vegetables.

Original languageEnglish (US)
Pages (from-to)650-661
Number of pages12
JournalJournal of the National Cancer Institute
Volume82
Issue number8
StatePublished - Apr 18 1990
Externally publishedYes

Fingerprint

Vegetables
Dietary Fiber
Nutrition
Colonic Neoplasms
Meta-Analysis
Cancer
Fiber
Diet
Fibers
Odds Ratio
Fruits
Case-control Study
Fruit
Observational Studies
Case-Control Studies
Epidemiologic Studies
Quantile
Estimate
Discrimination
Confidence interval

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging

Cite this

Dietary fiber, vegetables, and colon cancer : Critical review and meta-analyses of the epidemiologic evidence. / Trock, Bruce; Lanza, Elaine; Greenwald, Peter.

In: Journal of the National Cancer Institute, Vol. 82, No. 8, 18.04.1990, p. 650-661.

Research output: Contribution to journalArticle

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