Dietary fiber and distal coltrectal adenoma in men

Elizabeth A Platz, Edward Giovannucci, Eric B. Rimm, Helaine R H Rockett, Mein J. Stampfer, Graham A. Colditz, Walter C. Willett

Research output: Contribution to journalArticle

Abstract

We evaluated the relation of specific sources and components of fiber with diagnosis of distal colon (n = 531) or rectal (n = 159) adenomatous polyps or hyperplastic (n = 327) polyps in the Health Professionals Follow- up Study. We studied 16,448 men free of cancer or polyps in 1986, who underwent endoscopy in 19861994, and who provided diet and medical history. Relative risks (RRs) and 95% confidence intervals (CIs) adjusted using multiple logistic regression were calculated. We observed a modest reduced risk of distal colon adenoma with increasing intake of fiber from fruit (P- trend = 0.03) but not cereals or vegetables. The RR comparing the highest (median, 8.4 g/day) to lowest (1.3 g/day) quintile of fruit fiber intake was 0.81 (95% CI, 0.59-1.11). Soluble fiber, but not insoluble fiber, appeared to be inversely associated with distal colon adenoma (P-trend = 0.007). Comparing extreme quintiles (9.4 versus 3.4 g/day soluble fiber), the RR was 0.69 (95% CI, 0.46-1.03). Polyps detected in 1986 or later among men also with a negative endoscopy before 1986 may be considered to be 'incident,' with diet report corresponding more closely to time of polyp development. For 'incident' cases (n = 130), the relation between soluble fiber and distal colon adenoma was strengthened (extreme quintiles RR, 0.27; 95% CI, 0.11- 0.66; P-trend = 0.003), whereas for 'prevalent' cases (n = 401), we found no association. No consistent relation between fiber and rectal adenomas or hyperplastic polyps was observed. These results suggest that soluble fiber may he particularly important in reducing risk of adenomatous polyps of the distal colon and support national dietary guidelines of increasing fruit consumption.

Original languageEnglish (US)
Pages (from-to)661-670
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume6
Issue number9
StatePublished - 1997
Externally publishedYes

Fingerprint

Dietary Fiber
Adenoma
Polyps
Colon
Confidence Intervals
Adenomatous Polyps
Fruit
Endoscopy
Diet
Nutrition Policy
Vegetables
Logistic Models
Health
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Platz, E. A., Giovannucci, E., Rimm, E. B., Rockett, H. R. H., Stampfer, M. J., Colditz, G. A., & Willett, W. C. (1997). Dietary fiber and distal coltrectal adenoma in men. Cancer Epidemiology Biomarkers and Prevention, 6(9), 661-670.

Dietary fiber and distal coltrectal adenoma in men. / Platz, Elizabeth A; Giovannucci, Edward; Rimm, Eric B.; Rockett, Helaine R H; Stampfer, Mein J.; Colditz, Graham A.; Willett, Walter C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 6, No. 9, 1997, p. 661-670.

Research output: Contribution to journalArticle

Platz, EA, Giovannucci, E, Rimm, EB, Rockett, HRH, Stampfer, MJ, Colditz, GA & Willett, WC 1997, 'Dietary fiber and distal coltrectal adenoma in men', Cancer Epidemiology Biomarkers and Prevention, vol. 6, no. 9, pp. 661-670.
Platz EA, Giovannucci E, Rimm EB, Rockett HRH, Stampfer MJ, Colditz GA et al. Dietary fiber and distal coltrectal adenoma in men. Cancer Epidemiology Biomarkers and Prevention. 1997;6(9):661-670.
Platz, Elizabeth A ; Giovannucci, Edward ; Rimm, Eric B. ; Rockett, Helaine R H ; Stampfer, Mein J. ; Colditz, Graham A. ; Willett, Walter C. / Dietary fiber and distal coltrectal adenoma in men. In: Cancer Epidemiology Biomarkers and Prevention. 1997 ; Vol. 6, No. 9. pp. 661-670.
@article{987790af73734d57b83e1b1370bf5b0c,
title = "Dietary fiber and distal coltrectal adenoma in men",
abstract = "We evaluated the relation of specific sources and components of fiber with diagnosis of distal colon (n = 531) or rectal (n = 159) adenomatous polyps or hyperplastic (n = 327) polyps in the Health Professionals Follow- up Study. We studied 16,448 men free of cancer or polyps in 1986, who underwent endoscopy in 19861994, and who provided diet and medical history. Relative risks (RRs) and 95{\%} confidence intervals (CIs) adjusted using multiple logistic regression were calculated. We observed a modest reduced risk of distal colon adenoma with increasing intake of fiber from fruit (P- trend = 0.03) but not cereals or vegetables. The RR comparing the highest (median, 8.4 g/day) to lowest (1.3 g/day) quintile of fruit fiber intake was 0.81 (95{\%} CI, 0.59-1.11). Soluble fiber, but not insoluble fiber, appeared to be inversely associated with distal colon adenoma (P-trend = 0.007). Comparing extreme quintiles (9.4 versus 3.4 g/day soluble fiber), the RR was 0.69 (95{\%} CI, 0.46-1.03). Polyps detected in 1986 or later among men also with a negative endoscopy before 1986 may be considered to be 'incident,' with diet report corresponding more closely to time of polyp development. For 'incident' cases (n = 130), the relation between soluble fiber and distal colon adenoma was strengthened (extreme quintiles RR, 0.27; 95{\%} CI, 0.11- 0.66; P-trend = 0.003), whereas for 'prevalent' cases (n = 401), we found no association. No consistent relation between fiber and rectal adenomas or hyperplastic polyps was observed. These results suggest that soluble fiber may he particularly important in reducing risk of adenomatous polyps of the distal colon and support national dietary guidelines of increasing fruit consumption.",
author = "Platz, {Elizabeth A} and Edward Giovannucci and Rimm, {Eric B.} and Rockett, {Helaine R H} and Stampfer, {Mein J.} and Colditz, {Graham A.} and Willett, {Walter C.}",
year = "1997",
language = "English (US)",
volume = "6",
pages = "661--670",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "9",

}

TY - JOUR

T1 - Dietary fiber and distal coltrectal adenoma in men

AU - Platz, Elizabeth A

AU - Giovannucci, Edward

AU - Rimm, Eric B.

AU - Rockett, Helaine R H

AU - Stampfer, Mein J.

AU - Colditz, Graham A.

AU - Willett, Walter C.

PY - 1997

Y1 - 1997

N2 - We evaluated the relation of specific sources and components of fiber with diagnosis of distal colon (n = 531) or rectal (n = 159) adenomatous polyps or hyperplastic (n = 327) polyps in the Health Professionals Follow- up Study. We studied 16,448 men free of cancer or polyps in 1986, who underwent endoscopy in 19861994, and who provided diet and medical history. Relative risks (RRs) and 95% confidence intervals (CIs) adjusted using multiple logistic regression were calculated. We observed a modest reduced risk of distal colon adenoma with increasing intake of fiber from fruit (P- trend = 0.03) but not cereals or vegetables. The RR comparing the highest (median, 8.4 g/day) to lowest (1.3 g/day) quintile of fruit fiber intake was 0.81 (95% CI, 0.59-1.11). Soluble fiber, but not insoluble fiber, appeared to be inversely associated with distal colon adenoma (P-trend = 0.007). Comparing extreme quintiles (9.4 versus 3.4 g/day soluble fiber), the RR was 0.69 (95% CI, 0.46-1.03). Polyps detected in 1986 or later among men also with a negative endoscopy before 1986 may be considered to be 'incident,' with diet report corresponding more closely to time of polyp development. For 'incident' cases (n = 130), the relation between soluble fiber and distal colon adenoma was strengthened (extreme quintiles RR, 0.27; 95% CI, 0.11- 0.66; P-trend = 0.003), whereas for 'prevalent' cases (n = 401), we found no association. No consistent relation between fiber and rectal adenomas or hyperplastic polyps was observed. These results suggest that soluble fiber may he particularly important in reducing risk of adenomatous polyps of the distal colon and support national dietary guidelines of increasing fruit consumption.

AB - We evaluated the relation of specific sources and components of fiber with diagnosis of distal colon (n = 531) or rectal (n = 159) adenomatous polyps or hyperplastic (n = 327) polyps in the Health Professionals Follow- up Study. We studied 16,448 men free of cancer or polyps in 1986, who underwent endoscopy in 19861994, and who provided diet and medical history. Relative risks (RRs) and 95% confidence intervals (CIs) adjusted using multiple logistic regression were calculated. We observed a modest reduced risk of distal colon adenoma with increasing intake of fiber from fruit (P- trend = 0.03) but not cereals or vegetables. The RR comparing the highest (median, 8.4 g/day) to lowest (1.3 g/day) quintile of fruit fiber intake was 0.81 (95% CI, 0.59-1.11). Soluble fiber, but not insoluble fiber, appeared to be inversely associated with distal colon adenoma (P-trend = 0.007). Comparing extreme quintiles (9.4 versus 3.4 g/day soluble fiber), the RR was 0.69 (95% CI, 0.46-1.03). Polyps detected in 1986 or later among men also with a negative endoscopy before 1986 may be considered to be 'incident,' with diet report corresponding more closely to time of polyp development. For 'incident' cases (n = 130), the relation between soluble fiber and distal colon adenoma was strengthened (extreme quintiles RR, 0.27; 95% CI, 0.11- 0.66; P-trend = 0.003), whereas for 'prevalent' cases (n = 401), we found no association. No consistent relation between fiber and rectal adenomas or hyperplastic polyps was observed. These results suggest that soluble fiber may he particularly important in reducing risk of adenomatous polyps of the distal colon and support national dietary guidelines of increasing fruit consumption.

UR - http://www.scopus.com/inward/record.url?scp=0030765137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030765137&partnerID=8YFLogxK

M3 - Article

C2 - 9298572

AN - SCOPUS:0030765137

VL - 6

SP - 661

EP - 670

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 9

ER -