Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium

Caren E. Smith; Jack L. Follis; Jennifer A. Nettleton; Millennia Foy; Jason H Y Wu; Yiyi Ma; Toshiko Tanaka; Ani W. Manichakul; Hongyu Wu; Audrey Y. Chu; Lyn M. Steffen; Myriam Fornage; Dariush Mozaffarian; Edmond K. Kabagambe; Luigi Ferruci; Yii Der Ida Chen; Stephen S. Rich; Luc Djoussé; Paul M. Ridker; Weihong Tang; Barbara Mcknight; Michael Y. Tsai; Stefania Bandinelli; Jerome I. Rotter; Frank B. Hu; Daniel I. Chasman; Bruce M. Psaty; Donna K. Arnett; Irena B. King; Qi Sun; Lu Wang; Thomas Lumley; Stephanie E. Chiuve; David S. Siscovick; José M. Ordovás; Rozenn N. Lemaitre

doi:10.1002/mnfr.201400734

Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium

Caren E. Smith, Jack L. Follis, Jennifer A. Nettleton, Millennia Foy, Jason H Y Wu, Yiyi Ma, Toshiko Tanaka, Ani W. Manichakul, Hongyu Wu, Audrey Y. Chu, Lyn M. Steffen, Myriam Fornage, Dariush Mozaffarian, Edmond K. Kabagambe, Luigi Ferruci, Yii Der Ida Chen, Stephen S. Rich, Luc Djoussé, Paul M. Ridker, Weihong TangBarbara Mcknight, Michael Y. Tsai, Stefania Bandinelli, Jerome I. Rotter, Frank B. Hu, Daniel I. Chasman, Bruce M. Psaty, Donna K. Arnett, Irena B. King, Qi Sun, Lu Wang, Thomas Lumley, Stephanie E. Chiuve, David S. Siscovick, José M. Ordovás, Rozenn N. Lemaitre

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Scope: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. Methods and results: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid. Conclusion: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.

Original language	English (US)
Pages (from-to)	1373-1383
Number of pages	11
Journal	Molecular Nutrition and Food Research
Volume	59
Issue number	7
DOIs	https://doi.org/10.1002/mnfr.201400734
State	Published - Jul 1 2015
Externally published	Yes

Keywords

FADS1
Gene-diet interactions
Meta-analysis
Omega-3 fatty acids

ASJC Scopus subject areas

Biotechnology
Food Science

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10.1002/mnfr.201400734

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Smith, C. E., Follis, J. L., Nettleton, J. A., Foy, M., Wu, J. H. Y., Ma, Y., Tanaka, T., Manichakul, A. W., Wu, H., Chu, A. Y., Steffen, L. M., Fornage, M., Mozaffarian, D., Kabagambe, E. K., Ferruci, L., Chen, Y. D. I., Rich, S. S., Djoussé, L., Ridker, P. M., ... Lemaitre, R. N. (2015). Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. Molecular Nutrition and Food Research, 59(7), 1373-1383. https://doi.org/10.1002/mnfr.201400734

Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. / Smith, Caren E.; Follis, Jack L.; Nettleton, Jennifer A. et al.
In: Molecular Nutrition and Food Research, Vol. 59, No. 7, 01.07.2015, p. 1373-1383.

Research output: Contribution to journal › Article › peer-review

Smith, CE, Follis, JL, Nettleton, JA, Foy, M, Wu, JHY, Ma, Y, Tanaka, T, Manichakul, AW, Wu, H, Chu, AY, Steffen, LM, Fornage, M, Mozaffarian, D, Kabagambe, EK, Ferruci, L, Chen, YDI, Rich, SS, Djoussé, L, Ridker, PM, Tang, W, Mcknight, B, Tsai, MY, Bandinelli, S, Rotter, JI, Hu, FB, Chasman, DI, Psaty, BM, Arnett, DK, King, IB, Sun, Q, Wang, L, Lumley, T, Chiuve, SE, Siscovick, DS, Ordovás, JM & Lemaitre, RN 2015, 'Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium', Molecular Nutrition and Food Research, vol. 59, no. 7, pp. 1373-1383. https://doi.org/10.1002/mnfr.201400734

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title = "Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium",

abstract = "Scope: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. Methods and results: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid. Conclusion: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.",

keywords = "FADS1, Gene-diet interactions, Meta-analysis, Omega-3 fatty acids",

author = "Smith, {Caren E.} and Follis, {Jack L.} and Nettleton, {Jennifer A.} and Millennia Foy and Wu, {Jason H Y} and Yiyi Ma and Toshiko Tanaka and Manichakul, {Ani W.} and Hongyu Wu and Chu, {Audrey Y.} and Steffen, {Lyn M.} and Myriam Fornage and Dariush Mozaffarian and Kabagambe, {Edmond K.} and Luigi Ferruci and Chen, {Yii Der Ida} and Rich, {Stephen S.} and Luc Djouss{\'e} and Ridker, {Paul M.} and Weihong Tang and Barbara Mcknight and Tsai, {Michael Y.} and Stefania Bandinelli and Rotter, {Jerome I.} and Hu, {Frank B.} and Chasman, {Daniel I.} and Psaty, {Bruce M.} and Arnett, {Donna K.} and King, {Irena B.} and Qi Sun and Lu Wang and Thomas Lumley and Chiuve, {Stephanie E.} and Siscovick, {David S.} and Ordov{\'a}s, {Jos{\'e} M.} and Lemaitre, {Rozenn N.}",

year = "2015",

month = jul,

day = "1",

doi = "10.1002/mnfr.201400734",

language = "English (US)",

volume = "59",

pages = "1373--1383",

journal = "Molecular Nutrition and Food Research",

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TY - JOUR

T1 - Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes

T2 - Meta-analysis of nine studies in the CHARGE consortium

AU - Smith, Caren E.

AU - Follis, Jack L.

AU - Nettleton, Jennifer A.

AU - Foy, Millennia

AU - Wu, Jason H Y

AU - Ma, Yiyi

AU - Tanaka, Toshiko

AU - Manichakul, Ani W.

AU - Wu, Hongyu

AU - Chu, Audrey Y.

AU - Steffen, Lyn M.

AU - Fornage, Myriam

AU - Mozaffarian, Dariush

AU - Kabagambe, Edmond K.

AU - Ferruci, Luigi

AU - Chen, Yii Der Ida

AU - Rich, Stephen S.

AU - Djoussé, Luc

AU - Ridker, Paul M.

AU - Tang, Weihong

AU - Mcknight, Barbara

AU - Tsai, Michael Y.

AU - Bandinelli, Stefania

AU - Rotter, Jerome I.

AU - Hu, Frank B.

AU - Chasman, Daniel I.

AU - Psaty, Bruce M.

AU - Arnett, Donna K.

AU - King, Irena B.

AU - Sun, Qi

AU - Wang, Lu

AU - Lumley, Thomas

AU - Chiuve, Stephanie E.

AU - Siscovick, David S.

AU - Ordovás, José M.

AU - Lemaitre, Rozenn N.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Scope: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. Methods and results: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid. Conclusion: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.

AB - Scope: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. Methods and results: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid. Conclusion: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.

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KW - Gene-diet interactions

KW - Meta-analysis

KW - Omega-3 fatty acids

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Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium

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