TY - JOUR
T1 - Dietary fats, olive oil and respiratory diseases in Italian adults
T2 - A population-based study
AU - Cazzoletti, Lucia
AU - Zanolin, Maria Elisabetta
AU - Spelta, Francesco
AU - Bono, Roberto
AU - Chamitava, Liliya
AU - Cerveri, Isa
AU - Garcia-Larsen, Vanessa
AU - Grosso, Amelia
AU - Mattioli, Veronica
AU - Pirina, Pietro
AU - Ferrari, Marcello
N1 - Funding Information:
Funding information The GEIRD project was funded by: the Cariverona Foundation, the Italian Ministry of Health, Chiesi Farmaceutici, and the Agenzia Italiana del Farmaco (AIFA). The funders had no role in the design, in the collection, analysis and interpretation of the data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Roberta Vesentin and Roberto Marconcini are acknowledged for their contribution to the database management of the EPIC Food Frequency Questionnaire.
Funding Information:
The GEIRD project was funded by: the Cariverona Foundation, the Italian Ministry of Health, Chiesi Farmaceutici, and the Agenzia Italiana del Farmaco (AIFA). The funders had no role in the design, in the collection, analysis and interpretation of the data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2019 John Wiley & Sons Ltd
PY - 2019/6
Y1 - 2019/6
N2 - Background: Fat intake has been associated with respiratory diseases, with conflicting results. Objective: We studied the association between asthma and rhinitis with dietary fats, and their food sources in an Italian population. Methods: Clinical and nutritional information was collected for 871 subjects (aged 20-84) from the population-based multi-case-control study Genes Environment Interaction in Respiratory Diseases (GEIRD): 145 with current asthma (CA), 77 with past asthma (PA), 305 with rhinitis and 344 controls. Food intake was collected using the EPIC (European Investigation into Cancer and Nutrition) Food Frequency Questionnaire. The associations between fats and respiratory diseases were estimated by multinomial models. Fats and their dietary sources were analysed both as continuous variables and as quartiles. Results: Monounsaturated fatty acids and oleic acid were associated with a reduced risk of CA in both continuous (RRR = 0.68, 95%CI: 0.48; 0.96; RRR = 0.69; 95%CI: 0.49; 0.97, per 10 g, respectively) and per-quartile analyses (p for trend = 0.028 and 0.024, respectively). Olive oil was associated with a decreased risk of CA (RRR = 0.80; 95%CI: 0.65; 0.98 per 10 g). An increased risk of rhinitis was associated with moderate total fat and SFA intake. Conclusions: High dietary intakes of oleic acid and of olive oil are associated with a lower risk of asthma but not of rhinitis.
AB - Background: Fat intake has been associated with respiratory diseases, with conflicting results. Objective: We studied the association between asthma and rhinitis with dietary fats, and their food sources in an Italian population. Methods: Clinical and nutritional information was collected for 871 subjects (aged 20-84) from the population-based multi-case-control study Genes Environment Interaction in Respiratory Diseases (GEIRD): 145 with current asthma (CA), 77 with past asthma (PA), 305 with rhinitis and 344 controls. Food intake was collected using the EPIC (European Investigation into Cancer and Nutrition) Food Frequency Questionnaire. The associations between fats and respiratory diseases were estimated by multinomial models. Fats and their dietary sources were analysed both as continuous variables and as quartiles. Results: Monounsaturated fatty acids and oleic acid were associated with a reduced risk of CA in both continuous (RRR = 0.68, 95%CI: 0.48; 0.96; RRR = 0.69; 95%CI: 0.49; 0.97, per 10 g, respectively) and per-quartile analyses (p for trend = 0.028 and 0.024, respectively). Olive oil was associated with a decreased risk of CA (RRR = 0.80; 95%CI: 0.65; 0.98 per 10 g). An increased risk of rhinitis was associated with moderate total fat and SFA intake. Conclusions: High dietary intakes of oleic acid and of olive oil are associated with a lower risk of asthma but not of rhinitis.
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U2 - 10.1111/cea.13352
DO - 10.1111/cea.13352
M3 - Article
C2 - 30689281
AN - SCOPUS:85062346784
SN - 0954-7894
VL - 49
SP - 799
EP - 807
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
IS - 6
ER -